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Name Synonyms FDA Status Company Target Type Therapy Type Approved
For
Allopregnanolone brexanolone,
3α-hydroxy-5α-pregnan-20-one,
3α,5α-tetrahydroprogesterone
Alzheimer's Disease (Phase 2) Other Neurotransmitters, Other Small Molecule
Atomoxetine ATX,
Strattera
Alzheimer's Disease (Phase 2), Parkinson's Disease (Phase 1) Eli Lilly & Co. Other Neurotransmitters Small Molecule ADHD in US
Cannabidiol CBD,
Epidiolex
Alzheimer's Disease (Phase 2) Other Neurotransmitters Small Molecule Seizures in Dravet syndrome, Lennox-Gastaut syndrome or tuberous sclerosis complex
CST-103 Clenbuterol Mild Cognitive Impairment (Phase 2), Parkinson's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Phase 2) Other Neurotransmitters Small Molecule Asthma, in countries outside the U.S.
CST-2032 Mild Cognitive Impairment (Phase 2), Parkinson's Disease (Phase 2) CuraSen Therapeutics, Inc. Other Neurotransmitters Small Molecule
Dexpramipexole R-pramipexole,
RPPX,
KNS-760704 ,
BIIB 050
Alzheimer's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Discontinued) Biogen, Knopp Biosciences LLC, Virginia Commonwealth University Other Neurotransmitters, Other Small Molecule
Dronabinol THC ,
Marinol,
Syndros,
delta-9-tetrahydrocannabinol,
delta-9-THC
Alzheimer's Disease (Phase 2) AbbVie, Others Other Neurotransmitters Small Molecule Anorexia and weight loss in people with AIDS; Second-line treatment of nausea and vomiting due to chemotherapy
ORM-12741 Alzheimer's Disease (Phase 2) Orion Pharma Other Neurotransmitters Small Molecule
Piromelatine Neu-P11 Alzheimer's Disease (Phase 2) Neurim Pharmaceuticals Ltd. Other Neurotransmitters, Other Small Molecule
Rasagiline Rasagiline mesylate,
Azilect,
TVP-1012
Alzheimer's Disease (Phase 2), Parkinson's Disease (Approved), Amyotrophic Lateral Sclerosis (Inactive) Teva Other Neurotransmitters Small Molecule
Riluzole Rilutek®,
RP 54274
Alzheimer's Disease (Phase 2), Parkinson's Disease (Discontinued), Amyotrophic Lateral Sclerosis (Approved), Huntington's Disease (Discontinued) Sanofi Other Neurotransmitters, Other Small Molecule Amyotrophic Lateral Sclerosis in many countries
Rotigotine Neupro Alzheimer's Disease (Phase 2), Frontotemporal Dementia (Phase 2) UCB S.A. Other Neurotransmitters Small Molecule Parkinson's disease, Restless Leg Syndrome
SAGE-718 Alzheimer's Disease (Phase 2), Parkinson's Disease (Phase 2), Huntington's Disease (Phase 2) Sage Therapeutics, Inc. Other Neurotransmitters Small Molecule
Vafidemstat ORY-2001 Alzheimer's Disease (Phase 2) Oryzon Corporate Other Neurotransmitters Small Molecule