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Name Synonyms FDA Status Company Target Type Therapy Type Approved
For
AL002 Alzheimer's Disease (Phase 2) AbbVie, Alector Inflammation Immunotherapy (passive)
Baricitinib Olumiant®,
NCB28050,
LY3009104
Alzheimer's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Phase 1) Eli Lilly & Co. Inflammation Small Molecule Rheumatoid arthritis, Eczema (Europe, Japan only)
Benfotiamine S-benzoylthiamine-O-monophosphate,
Vitamin B1,
Thiamine
Alzheimer's Disease (Phase 2) Inflammation, Other Supplement, Dietary
CY6463 IW-6463 Alzheimer's Disease (Phase 2) Cyclerion Inflammation Small Molecule
Etanercept Enbrel™ Alzheimer's Disease (Phase 2) Amgen, Inc., Pfizer Inflammation Immunotherapy (passive) Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondilysis
GRF6019 Alzheimer's Disease (Phase 2) Alkahest, Inc., Grifols Biologicals Inc. Inflammation, Other, Unknown Other
Lenalidomide Revlimid Alzheimer's Disease (Phase 2) Celgene Corporation Amyloid-Related, Inflammation Small Molecule Multiple myeloma, lymphoma, myelodysplastic syndromes
Lomecel-B mesenchymal stem cells Alzheimer's Disease (Phase 2) Longeveron Inflammation, Other Other
Montelukast Singulair, MK0476 Alzheimer's Disease (Phase 2) Intelgenx Inflammation Small Molecule Asthma
MW150 MW01-18-150SRM Alzheimer's Disease (Phase 2) Neurokine Therapeutics Inflammation, Other Small Molecule
Neflamapimod VX-745 Alzheimer's Disease (Phase 2), Dementia with Lewy Bodies (Phase 2), Huntington's Disease (Discontinued) CervoMed, Inc. Inflammation Small Molecule
Sargramostim GM-CSF Leukine ,
Leukine®
Alzheimer's Disease (Phase 2), Parkinson's Disease (Phase 1) Genzyme, Partner Therapeutics, Inc., Sanofi Inflammation, Other, Unknown Other Bone Marrow Stimulation
Varoglutamstat PQ912 Alzheimer's Disease (Phase 2) Probiodrug AG, Vivoryon Therapeutics N.V. Amyloid-Related, Inflammation Small Molecule
XPro1595 Pegipanermin, INB03, NeuLiv, XENP1595, DN-TNF, XENP345,
XPro™ ,
LIVNate
Alzheimer's Disease (Phase 2), Mild Cognitive Impairment (Phase 2) INmune Bio Inc. Inflammation Other