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Name Synonyms FDA Status Company Target Type Therapy Type Approved
For
AAV2-BDNF MCI due to AD (Phase 1), Alzheimer's Disease (Phase 1) Other DNA/RNA-based
ALN-APP Alzheimer's Disease (Phase 1) Alnylam Pharmaceuticals, Inc., Regeneron Pharmaceuticals Inc. Amyloid-Related DNA/RNA-based
BIIB080 IONIS-MAPTRx,
ISIS 814907
Alzheimer's Disease (Phase 1) Biogen, IONIS Pharmaceuticals Tau DNA/RNA-based
CpG 1018® CpG oligodeoxynucleotides,
CpG ODN
Alzheimer's Disease (Phase 1) Dynavax Technologies Amyloid-Related, Inflammation Immunotherapy (active), DNA/RNA-based
LX1001 AAVrh.10-APOE2,
AAVrh.10hAPOE2
Alzheimer's Disease (Phase 1) Lexeo Therapeutics Amyloid-Related DNA/RNA-based
NIO752 Progressive Supranuclear Palsy (Phase 1), Alzheimer's Disease (Phase 1) Novartis Pharmaceuticals Corporation Tau DNA/RNA-based