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Name Synonyms FDA Status Company Target Type Therapy Type Approved
For
LMTM TRx0237, LMT-X,
Methylene Blue,
Tau aggregation inhibitor (TAI)
Alzheimer's Disease (Phase 3), Frontotemporal Dementia (Phase 3) TauRx Therapeutics Ltd Tau Small Molecule Methylene Blue predates FDA. Used for treatment of malaria and methemoglobinemia.
Neflamapimod VX-745 Alzheimer's Disease (Phase 2) EIP Pharma, LLC Inflammation Small Molecule
AAB-003 PF-05236812 Alzheimer's Disease (Phase 1) Janssen, Pfizer Amyloid-Related Immunotherapy (passive)
AADvac-1 Axon peptide 108 conjugated to KLH Alzheimer's Disease (Phase 2) Axon Neuroscience SE Tau Immunotherapy (active)
ABT 418 Alzheimer's Disease (Discontinued) Cholinergic System Small Molecule None
ABT-089 Alzheimer's Disease (Discontinued) Abbott Laboratories Cholinergic System Small Molecule
ABT-288 Alzheimer's Disease (Discontinued) AbbVie Cholinergic System, Other Neurotransmitters Small Molecule
ABT-384 Alzheimer's Disease (Discontinued) AbbVie Other Small Molecule
ABT-957 Alzheimer's Disease (Phase 1) AbbVie Other Small Molecule
ABvac 40 Alzheimer's Disease (Phase 2) Araclon Biotech Amyloid-Related Immunotherapy (active)
AC-1204 Caprylic triglyceride,
Long-chain triglycerides
Alzheimer's Disease (Phase 2/3) Accera, Inc. Other Other None
ACI-24 Pal1-15 acetate salt Alzheimer's Disease (Phase 1/2), Down's Syndrome (Phase 1) AC Immune SA Amyloid-Related Immunotherapy (active)
ACI-35 Alzheimer's Disease (Phase 1) AC Immune SA, Janssen Tau Immunotherapy (active)
AF 102B cevimeline HCL,
Evoxac™
Alzheimer's Disease (Discontinued) SnowBrand Pharmaceuticals, Inc. Cholinergic System Small Molecule Treatment of dry mouth in Sjogren's syndrome.
AGB101 Levetiracetam,
Keppra
Mild Cognitive Impairment (Phase 3), Parkinson's Disease (Discontinued) AgeneBio, Inc. Amyloid-Related, Other Small Molecule Epilepsy and Partial Seizures in U.S., European Union, plus about 20 other countries
ALZT-OP1 Cromolyn sodium, Intal,
Ibuprofen
Alzheimer's Disease (Phase 3) AZTherapies, Inc. Amyloid-Related, Inflammation Small Molecule
AN-1792 AIP 001 Alzheimer's Disease (Discontinued) Janssen, Pfizer Amyloid-Related Immunotherapy (active) None
AVP-786 Alzheimer's Disease (Phase 3), Schizophrenia (Phase 2) Avanir Pharmaceuticals, Concert Pharmaceuticals, Inc., Otsuka Pharmaceutical Co., Ltd. Other Neurotransmitters Small Molecule
AVP-923 Nuedexta,
Zenvia
Alzheimer's Disease (Phase 4), Amyotrophic Lateral Sclerosis (Phase 3), Parkinson's Disease (Phase 3) Avanir Pharmaceuticals Other Neurotransmitters Small Molecule
AZD1446 TC-6683 Alzheimer's Disease (Discontinued) AstraZeneca, Targacept Cholinergic System Small Molecule None
AZD3480 ispronicline,
TC-1734
Alzheimer's Disease (Inactive) AstraZeneca, Targacept Cholinergic System Small Molecule
Acetyl-l-carnitine HCI ALCAR Alzheimer's Disease (Discontinued) Sigma-Tau Pharmaceuticals Other Dietary Supplement
Acitretin Soriatane ,
Neotigason,
RO 101670
Alzheimer's Disease (Phase 2) Actavis, Allergan plc Amyloid-Related Small Molecule Psoriasis in US
Aducanumab BIIB037 Alzheimer's Disease (Phase 3) Biogen Amyloid-Related Immunotherapy (passive)
Affitope AD02 Alzheimer's Disease (Phase 2) AFFiRiS AG Amyloid-Related Immunotherapy (active)
Allopregnanolone 3α,5α-tetrahydroprogesterone,
3α-hydroxy-5α-pregnan-20-one
Alzheimer's Disease (Phase 1) Other Neurotransmitters, Other Small Molecule
Alpha-Tocopherol Vitamin E Alzheimer's Disease (Phase 3) Other Dietary Supplement
Alzhemed™ Vivimind™,
Tramiprosate,
NC-531,
homotaurine,
3-APS
Alzheimer's Disease (Inactive) Neurochem, Inc. Amyloid-Related Dietary Supplement None
Anavex 2-73 Alzheimer's Disease (Phase 2) Anavex Life Science Corp. Other Small Molecule
Aripiprazole Abilify,
BMS-337039
Alzheimer's Disease (Phase 3), Schizophrenia (Approved) Bristol-Myers Squibb, Otsuka Pharmaceutical Co., Ltd. Other Neurotransmitters Small Molecule
Atomoxetine ATX,
Strattera
Alzheimer's Disease (Discontinued) Eli Lilly & Co. Other Neurotransmitters Small Molecule ADHD in US
Atorvastatin Lipitor™ ,
Zarator®,
Sortis®,
Tahor®
Alzheimer's Disease (Inactive) Pfizer Cholesterol Small Molecule Hypercholesterolaemia
Avagacestat BMS-708163 Alzheimer's Disease (Discontinued) Bristol-Myers Squibb Amyloid-Related Small Molecule
Azeliragon PF-04494700 ,
TTP488
Alzheimer's Disease (Phase 3) Pfizer, TransTech Pharma, Inc., vTv Therapeutics LLC Amyloid-Related, Inflammation Small Molecule
BAN2401 Alzheimer's Disease (Phase 2) Biogen, Eisai Co., Ltd. Amyloid-Related Immunotherapy (passive)
BI 1181181 VTP 37948,
BACE inhibitor
Alzheimer's Disease (Discontinued) Boehringer Ingelheim, Vitae Pharmaceuticals Amyloid-Related Small Molecule
BI 409306 SUB 166499 Alzheimer's Disease (Phase 2) Boehringer Ingelheim Other Neurotransmitters, Other Small Molecule
BIIB092 BMS-986168, IPN007 Progressive Supranuclear Palsy (Phase 1) Biogen, Bristol-Myers Squibb Tau Immunotherapy (passive)
Bapineuzumab AAB-001 Alzheimer's Disease (Discontinued) Janssen, Pfizer Amyloid-Related Immunotherapy (passive)
Besipirdine HCl HP 749 Alzheimer's Disease (Discontinued) Aventis Pharmaceuticals, Inc. (was Hoechst) Other Neurotransmitters Small Molecule
Bexarotene Targretin® Alzheimer's Disease (Phase 2) Ligand Pharmaceuticals, Inc., ReXceptor Inc. Amyloid-Related, Unknown Small Molecule Cutaneous T-cell Lymphoma in US
Brexpiprazole Rexulti,
OPC 34712
Alzheimer's Disease (Phase 3), Schizophrenia (Approved) H. Lundbeck, Otsuka Pharmaceutical Co., Ltd. Other Neurotransmitters Small Molecule
C2N 8E12 ABBV-8E12 Progressive Supranuclear Palsy (Phase 1), Alzheimer's Disease (Phase 2) AbbVie, C2N Diagnostics, LLC Tau Immunotherapy (passive)
CAD106 Alzheimer's Disease (Phase 2/3) Novartis Pharmaceuticals Corporation Amyloid-Related Immunotherapy (active) None
CERE-110 Nerve Growth Factor gene therapy Alzheimer's Disease (Discontinued) Sangamo BioSciences, Inc. Other Gene/Stem Cell
CHF 5074 Mild Cognitive Impairment (Phase 2), Alzheimer's Disease (Inactive) CereSpir™ Incorporated, Chiesi Pharmaceuticals Inc. Amyloid-Related, Inflammation, Other Small Molecule
CNP520 BACE Inhibitor Alzheimer's Disease (Phase 2/3) Amgen, Inc., Novartis Pharmaceuticals Corporation Amyloid-Related Small Molecule
COGNIShunt™ Alzheimer's Disease (Inactive) Other Procedural Intervention None
CT1812 Alzheimer's Disease (Phase 1/2) Cognition Therapeutics Inc. Amyloid-Related Small Molecule
CX516 Ampalex Alzheimer's Disease (Discontinued) Cortex Pharmaceuticals, Inc. Other Neurotransmitters Small Molecule None
Carvedilol Coreg,
Artist ,
Aucardic,
Dilatrend,
Kredex
Alzheimer's Disease (Phase 4) Procter & Gamble Unknown Small Molecule Hypertension, heart failure, angina pectoris
Celecoxib Celebrex Alzheimer's Disease (Discontinued) Pfizer Inflammation Small Molecule Pain, Arthritis
Cerebrolysin Alzheimer's Disease (Phase 2) Ebewe Pharmaceutical Other Other
Circadin Alzheimer's Disease (Phase 2) Neurim Pharmaceuticals Ltd. Other Small Molecule Insomnia
Clioquinol iodochlorhydroxyquin,
PBT-1
Alzheimer's Disease (Discontinued) Prana Biotechnology Limited Amyloid-Related, Metals Small Molecule
Continuous Positive Airway Pressure CPAP Alzheimer's Disease (Phase 3) Unknown Procedural Intervention Sleep Apnea in US
Crenezumab MABT5102A ,
RG7412
Alzheimer's Disease (Phase 3) AC Immune SA, Genentech, Hoffmann-La Roche Amyloid-Related Immunotherapy (passive) None
Curcumin diferuloylmethane,
Longvida™
Alzheimer's Disease (Phase 2) Verdure Sciences Other, Unknown Dietary Supplement None
Dapsone Avlosulfon,
Diaminodiphenylsulfone,
DDS
Alzheimer's Disease (Inactive) Immune Network Ltd. Other Small Molecule Leprosy, malaria, some bacterial skin infections
Davunetide NAP,
AL-108
Mild Cognitive Impairment (Inactive), Progressive Supranuclear Palsy (Inactive), Schizophrenia (Inactive), Frontotemporal Dementia (Inactive) Allon Therapeutics Inc., Paladin Labs Inc. Tau Other
Deep Brain Stimulation-fornix Alzheimer's Disease (Phase 2) Functional Neuromodulation Ltd Unknown Procedural Intervention
Dexpramipexole R-pramipexole,
RPPX,
KNS-760704 ,
BIIB 050
Alzheimer's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Discontinued) Biogen, Knopp Biosciences LLC, Virginia Commonwealth University Other Neurotransmitters, Other Small Molecule
Dimebon Dimebolin,
Latrepirdine,
Pf-01913539
Alzheimer's Disease (Discontinued), Huntington's Disease (Discontinued) Medivation, Inc. Other Neurotransmitters, Unknown Small Molecule Anti-histamine use in Russia
Docosahexaenoic acid (DHA) Omega 3 fatty acid Alzheimer's Disease (Phase 4) Martek Biosciences Corporation, NeuroBioPharm, Inc. Other Dietary Supplement
Donepezil Aricept™,
Donepezil hydrochloride,
Eranz®,
E 2020
Alzheimer's Disease (Approved), Dementia with Lewy Bodies (Phase 3), Down's Syndrome (Phase 2), Parkinson's Disease Dementia (Phase 3) Eisai Co., Ltd., Pfizer Cholinergic System Small Molecule Alzheimer's Disease
EHT 0202 Etazolate Alzheimer's Disease (Phase 2) ExonHit Therapeutics Other Small Molecule None
ELND005 AZD-103,
Scyllo-inositol,
cyclohexane-1,2,3,4,5,6-hexol
Alzheimer's Disease (Phase 2) Elan Corporation, Speranza Therapeutics, Transition Therapeutics, Inc. Amyloid-Related Small Molecule None
EVP-0962 EVP 0015962 Alzheimer's Disease (Phase 2), Mild Cognitive Impairment (Phase 2) FORUM Pharmaceuticals Inc. Amyloid-Related Small Molecule
Edonerpic T-817 MA, T 817 Alzheimer's Disease (Phase 2) Toyama Chemical Co., Ltd. Other, Unknown Small Molecule
Elenbecestat E2609,
BACE inhibitor
Alzheimer's Disease (Phase 3) Biogen, Eisai Co., Ltd. Amyloid-Related Small Molecule
Encenicline EVP-6124 ,
MT-4666,
α7-nAChR agonist
Alzheimer's Disease (Discontinued), Schizophrenia (Discontinued) FORUM Pharmaceuticals Inc., Mitsubishi Tanabe Pharma Cholinergic System Small Molecule None
Epigallocatechin Gallate (EGCG) Sunphenon EGCg Alzheimer's Disease (Phase 2/3), Down's Syndrome (Phase 2), Multiple System Atrophy (Phase 3) Taiyo International Amyloid-Related, Inflammation, Other Dietary Supplement
Epothilone D BMS-241027 Alzheimer's Disease (Discontinued) Bristol-Myers Squibb Tau Small Molecule
Eptastigmine MF 201 Alzheimer's Disease (Discontinued) Mediolanum Cholinergic System Small Molecule None
Estrogen Premarin™ Alzheimer's Disease (Discontinued) Other Other Hormone Replacement Therapy
Etanercept Enbrel™ Alzheimer's Disease (Phase 2) Amgen, Inc., Pfizer Inflammation Immunotherapy (passive) Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondilysis
Exendin-4 Exenatide,
Byetta,
Bydureon
Alzheimer's Disease (Phase 2) Other Small Molecule Diabetes mellitus in US
FRM-0334 EVP-0334 Frontotemporal Dementia (Phase 2) FORUM Pharmaceuticals Inc. Other Small Molecule
Flurizan™ tarenflurbil ,
r-flurbiprofen,
MPC-7869
Alzheimer's Disease (Discontinued) Myriad Genetics & Laboratories Amyloid-Related Small Molecule None
G-CSF Filgrastim Alzheimer's Disease (Phase 2) Other Small Molecule Neutropenia in US
GC 021109 Alzheimer's Disease (Phase 1) GliaCure Inflammation Small Molecule
GLN-1062 Memogain Alzheimer's Disease (Phase 1) Galantos Pharma, Neurodyn Cholinergic System Small Molecule
GSK239512 Alzheimer's Disease (Discontinued) GlaxoSmithKline (GSK) Cholinergic System, Other Neurotransmitters Small Molecule
GSK2647544 GSK-2647544 Alzheimer's Disease (Phase 1) GlaxoSmithKline (GSK) Cholesterol Small Molecule
GSK933776 Alzheimer's Disease (Inactive) GlaxoSmithKline (GSK) Amyloid-Related Immunotherapy (passive)
Galantamine Razadyne™,
Reminyl™,
Nivalin®
Alzheimer's Disease (Approved) Janssen, Ortho-McNeil Pharmaceutical, Sanochemia Pharmazeutika, Shire, Takeda Pharmaceutical Company Cholinergic System Small Molecule Mild to Moderate Alzheimer's disease
Gammagard® Intravenous Immunoglobulin,
IVIg
Alzheimer's Disease (Discontinued) Baxter Healthcare Amyloid-Related, Inflammation Immunotherapy (passive) Immunodeficiency conditions
Gamunex Intravenous Immunoglobulin,
Human Albumin Combined With Flebogamma
Alzheimer's Disease (Phase 2/3) Grifols Biologicals Inc. Amyloid-Related, Inflammation Immunotherapy (passive) Immunodeficiency, chronic inflammatory demyelinating neuropathy
Gantenerumab RO4909832,
RG1450
Alzheimer's Disease (Phase 3) Chugai Pharmaceutical Co., Ltd., Hoffmann-La Roche Amyloid-Related Immunotherapy (passive)
Gemfibrozil Lopid,
Jezil,
Gen-Fibro
Alzheimer's Disease (Phase 0) Cholesterol Small Molecule Hyperlipidemia
HF0220 Alzheimer's Disease (Discontinued) Newron Inflammation Small Molecule
Huperzine A ZT-1,
DEBIO 9902 ,
Qian ceng ta,
Cerebra capsule,
Pharmassure Memorall capsule
Alzheimer's Disease (Inactive) Debiopharm Group™, Neuro-Hitech, Inc. Cholinergic System Small Molecule, Dietary Supplement None
Ibuprofen Advil™,
Nuprin™ ,
Motrin™
Alzheimer's Disease (Discontinued) Amyloid-Related, Inflammation Small Molecule Pain and Fever
Idalopirdine Lu AE58054,
SGS 518
Alzheimer's Disease (Phase 3), Schizophrenia (Inactive) H. Lundbeck, Otsuka Pharmaceutical Co., Ltd. Other Neurotransmitters Small Molecule
Idebenone Catena,
Sovrima
Alzheimer's Disease (Discontinued) Takeda Pharmaceutical Company Other Small Molecule None
Intepirdine RVT-101,
SB 742457 ,
GSK 742457
Alzheimer's Disease (Inactive), Dementia with Lewy Bodies (Phase 2/3) Axovant Sciences Ltd. Other Neurotransmitters Small Molecule
JNJ-54861911 BACE inhibitor Alzheimer's Disease (Phase 2/3) Janssen, Shionogi Pharma Amyloid-Related Small Molecule
Ketasyn Axona,
Caprylic Acid,
AC-1202
Alzheimer's Disease (Phase 4) Accera, Inc. Other Dietary Supplement
LU25-109 Alzheimer's Disease (Discontinued) Cholinergic System Small Molecule None
LY2599666 Alzheimer's Disease (Phase 1) Eli Lilly & Co. Amyloid-Related Immunotherapy (passive)
LY2886721 BACE inhibitor Alzheimer's Disease (Discontinued), Mild Cognitive Impairment (Discontinued) Eli Lilly & Co. Amyloid-Related Small Molecule
LY3002813 N3pG-Aβ Monoclonal Antibody Alzheimer's Disease (Phase 1) Eli Lilly & Co. Amyloid-Related Immunotherapy (passive)
LY3202626 BACE Inhibitor Alzheimer's Disease (Phase 2) Eli Lilly & Co. Amyloid-Related Small Molecule
LY3303560 Alzheimer's Disease (Phase 1) Eli Lilly & Co. Unknown Immunotherapy (passive)
Ladostigil Ladostigil hemitartrate,
TV3326
Mild Cognitive Impairment (Phase 2), Alzheimer's Disease (Discontinued) Avraham Pharmaceuticals Ltd Cholinergic System Small Molecule
Lanabecestat AZD3293 ,
LY3314814,
BACE inhibitor
Alzheimer's Disease (Phase 3) AstraZeneca, Eli Lilly & Co. Amyloid-Related Small Molecule
Leuprolide Leuprolide acetate Alzheimer's Disease (Discontinued) Other Other None
Linopirdine DuP996 Alzheimer's Disease (Discontinued) Other Small Molecule None
Liraglutide Victoza™ Alzheimer's Disease (Phase 2) Novo Nordisk A/S Other Small Molecule
Lornoxicam Alzheimer's Disease (Discontinued), Mild Cognitive Impairment (Discontinued) JSW Lifesciences Inflammation Small Molecule Pain in US
Lu AF20513 Alzheimer's Disease (Phase 1) H. Lundbeck, Otsuka Pharmaceutical Co., Ltd. Amyloid-Related Immunotherapy (active)
Lumateperone ITI-007 Alzheimer's Disease (Phase 3), Schizophrenia (Phase 3), Bipolar Disorder (Phase 3) Bristol-Myers Squibb, Intra-Cellular Therapies, Inc. Other Neurotransmitters Small Molecule
MEDI1814 Alzheimer's Disease (Phase 1) Eli Lilly & Co. Amyloid-Related Immunotherapy (passive)
MEM 1003 BAY Z 4406 Alzheimer's Disease (Discontinued), Mild Cognitive Impairment (Discontinued), Vascular Dementia (Discontinued), Bipolar Disorder (Discontinued) Memory Pharmaceuticals Corporation Other Small Molecule None
MK-7622 Alzheimer's Disease (Discontinued) Merck Unknown Small Molecule
MKC-231 Alzheimer's Disease (Inactive) Mitsubishi Tanabe Pharma Unknown Small Molecule None
MSDC-0160 Mitoglitazone Alzheimer's Disease (Phase 2) Metabolic Solutions Development Company Other Small Molecule
Masitinib Masivet,
Kinavet,
AB1010,
Masitinib mesylate
Alzheimer's Disease (Phase 3), Amyotrophic Lateral Sclerosis (Phase 3) AB Science Other Small Molecule
Melatonin Alzheimer's Disease (Phase 2) Other Dietary Supplement None
Memantine Ebixa™,
Namenda™ ,
Axura®,
Akatinol®,
Memary®
Alzheimer's Disease (Approved) Forest Laboratories, Inc., H. Lundbeck, Merz Pharma Other Neurotransmitters Small Molecule Alzheimer's Disease
Metrifonate trichlorfon Alzheimer's Disease (Discontinued) Cholinergic System Small Molecule None
Milameline CI 979 Alzheimer's Disease (Discontinued) Aventis Pharmaceuticals, Inc. (was Hoechst) Cholinergic System Small Molecule None
Minocycline Solodyn,
Arestin,
Minocin,
Dynacin
Alzheimer's Disease (Phase 2) Inflammation Small Molecule
NGX267 AF267B Alzheimer's Disease (Inactive) TorreyPines Therapeutics, Inc. Cholinergic System Small Molecule None
NIC5-15 Pinitol,
D-Pinitol
Alzheimer's Disease (Phase 2) Humanetics Pharmaceuticals Corporation Amyloid-Related, Other Small Molecule, Dietary Supplement
NS2330 Tesofensine Alzheimer's Disease (Discontinued) NeuroSearch A/S Other Neurotransmitters Small Molecule
Naproxen Aleve™,
Anaprox™,
Naprosyn™
Alzheimer's Disease (Discontinued) Procter & Gamble Inflammation Small Molecule Over-the-counter drug for reduction of pain, fever, inflammation, and stiffness.
Nasal Insulin Detemir,
Levemir,
Humulin,
Novolin
Alzheimer's Disease (Phase 2/3), Mild Cognitive Impairment (Phase 2), Parkinson's Disease (Phase 2), Multiple System Atrophy (Phase 2) Amyloid-Related, Other Small Molecule, Other Diabetes
Nefiracetam Alzheimer's Disease (Discontinued) Daiichi Sankyo Pharmaceuticals Cholinergic System Small Molecule None
Nelonicline ABT-126 Alzheimer's Disease (Discontinued), Schizophrenia (Inactive) AbbVie Cholinergic System Small Molecule
Nelotanserin APD-125 Dementia with Lewy Bodies (Phase 2) Axovant Sciences Ltd. Other Neurotransmitters Small Molecule
NeoTrofin AIT-082,
leteprinim
Alzheimer's Disease (Discontinued) NeoTherapeutics, Inc. Unknown Small Molecule None
Neramexane MRZ 2/579 Alzheimer's Disease (Discontinued) Forest Laboratories, Inc., Merck Other Neurotransmitters Small Molecule None
Nicotinamide Enduramide,
Niacinamide,
Nicotinic acid amide,
Vitamin B3
Alzheimer's Disease (Phase 2) Other Small Molecule
Nilvadipine Nilvad,
Nivadil,
ARC029
Alzheimer's Disease (Phase 3) Archer Pharmaceuticals, Inc. Other Small Molecule
Nimodipine Nimotop Frontotemporal Dementia (Phase 1) Bayer Metals Small Molecule Subarachnoid hemorrhage
ORM-12741 Alzheimer's Disease (Phase 2) Orion Pharma Other Neurotransmitters Small Molecule
Octagam®10% Intravenous Immunoglobulin,
NewGam
Alzheimer's Disease (Inactive), Mild Cognitive Impairment (Inactive) Octapharma Amyloid-Related, Inflammation Immunotherapy (passive) Immunodeficiency disorders
PBT2 PBT-2 Alzheimer's Disease (Phase 2), Huntington's Disease (Phase 2) Prana Biotechnology Limited Amyloid-Related, Metals Small Molecule
PF-05212377 PF-5212377,
WYE-103760,
SAM-760
Alzheimer's Disease (Inactive) Pfizer Other Neurotransmitters Small Molecule
PF-05251749 Alzheimer's Disease (Phase 1) Pfizer Unknown Small Molecule
PF-06648671 Alzheimer's Disease (Phase 1) Pfizer Amyloid-Related Small Molecule
PF-06751979 Alzheimer's Disease (Phase 1) Pfizer Unknown Small Molecule
PQ912 Alzheimer's Disease (Phase 2) Probiodrug AG Amyloid-Related, Inflammation Small Molecule
PRX-03140 Potassium salt Alzheimer's Disease (Inactive) Epix Pharmaceuticals Other Small Molecule
PRX002 RG7935, NEOD002 Parkinson's Disease (Phase 1) Prothena Corporation plc, Roche alpha-synuclein Immunotherapy (passive)
PXT864 PXT00864 Alzheimer's Disease (Phase 2) Pharnext Other Neurotransmitters Small Molecule
Phenserine Alzheimer's Disease (Inactive) TorreyPines Therapeutics, Inc. Cholinergic System Small Molecule
Physostigmine Salicylate Synapton Alzheimer's Disease (Discontinued) Forest Laboratories, Inc. Cholinergic System Small Molecule
Pimavanserin Nuplazid,
ACP-103,
Pimavanserin tartrate
Alzheimer's Disease (Phase 2), Schizophrenia (Phase 3) Acadia Pharmaceuticals Other Neurotransmitters Small Molecule Parkinson's psychosis
Pioglitazone AD4833,
Actos®,
Glustin™,
Piozone®
Mild Cognitive Impairment (Phase 3) Takeda Pharmaceutical Company, Zinfandel Pharmaceuticals Inc. Inflammation, Other Small Molecule Type 2 diabetes mellitus
Piromelatine Neu-P11 Alzheimer's Disease (Phase 2) Neurim Pharmaceuticals Ltd. Other Neurotransmitters, Other Small Molecule
Ponezumab PF-04360365 Alzheimer's Disease (Discontinued), Cerebral Amyloid Angiopathy (Phase 2) Pfizer Amyloid-Related Immunotherapy (passive) None
Prazosin Prazosin hydrochloride,
Minipress,
Hypovase,
Vasoflex
Alzheimer's Disease (Phase 4) Other Neurotransmitters Small Molecule Hypertension
Prednisone Alzheimer's Disease (Discontinued) Inflammation Small Molecule
Propentofylline HWA 285,
PPF
Alzheimer's Disease (Discontinued) Unknown Small Molecule
RG3487 RO5313534,
MEM 3454
Alzheimer's Disease (Inactive) Roche Cholinergic System Small Molecule
RG7129 RO5508887,
BACE Inhibitor
Alzheimer's Disease (Discontinued) Roche Amyloid-Related Small Molecule
RG7345 RO6926496 Alzheimer's Disease (Discontinued) Roche Tau Immunotherapy (passive)
RO 7105705 RG 6100 Alzheimer's Disease (Phase 1) AC Immune SA, Genentech, Hoffmann-La Roche Tau Immunotherapy (passive)
Rember TM Methylene Blue ,
methylthioninium (MT),
TRx-0014,
Tau aggregation inhibitor (TAI)
Alzheimer's Disease (Discontinued) TauRx Therapeutics Ltd Tau Small Molecule Methylene Blue predates FDA. Used for treatment of malaria and methemoglobinemia.
Repetitive Transcranial Magnetic Stimulation rTMS Alzheimer's Disease (Phase 2) Neuronix Ltd Other Procedural Intervention
Resveratrol trans-3,4',5-trihydroxystilbene Alzheimer's Disease (Phase 3), Mild Cognitive Impairment (Phase 4) Other Small Molecule, Dietary Supplement
Rilapladib SB-659032 Alzheimer's Disease (Phase 2) GlaxoSmithKline (GSK) Other Small Molecule
Riluzole Rilutek®,
RP 54274
Alzheimer's Disease (Phase 2), Parkinson's Disease (Discontinued), Amyotrophic Lateral Sclerosis (Approved), Huntington's Disease (Discontinued) Sanofi Other Neurotransmitters, Other Small Molecule Amyotrophic Lateral Sclerosis in many countries
Rivastigmine Exelon™,
Rivastigmine tartrate ,
Rivastach® Patch,
Prometax®,
SDZ ENA 713
Alzheimer's Disease (Approved), Parkinson's Disease Dementia (Approved) Novartis Pharmaceuticals Corporation Cholinergic System Small Molecule Mild to moderate Alzheimer’s disease and mild to moderate dementia related to Parkinson's disease
Rofecoxib Vioxx™ Alzheimer's Disease (Discontinued) Merck Inflammation Small Molecule Withdrawn from market
Rosiglitazone Rosiglitazone maleate,
Avandia
Alzheimer's Disease (Discontinued) GlaxoSmithKline (GSK) Other Small Molecule
S 38093 Alzheimer's Disease (Discontinued) Servier Cholinergic System, Other Neurotransmitters Small Molecule
S-Equol Aus-131 Alzheimer's Disease (Phase 1) Ausio Pharmaceuticals, LLC Other Small Molecule
S47445 CX1632 Alzheimer's Disease (Phase 2) Cortex Pharmaceuticals, Inc., Servier Other Neurotransmitters Small Molecule
SAR110894D Alzheimer's Disease (Phase 2) Sanofi Other Small Molecule
SAR228810 Alzheimer's Disease (Phase 1) Sanofi Amyloid-Related Immunotherapy (passive)
SB 202026 Memric Alzheimer's Disease (Discontinued) Other Neurotransmitters Small Molecule
SGS-742 CGP-36742,
DVD-742
Alzheimer's Disease (Discontinued) Novartis Pharmaceuticals Corporation, Saegis Pharmaceuticals, Inc. Other Neurotransmitters Small Molecule
ST101 ZSET1446 Alzheimer's Disease (Inactive) Sonexa Therapeutics, Inc. Unknown Small Molecule
SUVN-502 Alzheimer's Disease (Phase 2) Suven Life Sciences Ltd Other Neurotransmitters Small Molecule
SUVN-G3031 Alzheimer's Disease (Phase 1) Suven Life Sciences Ltd Cholinergic System, Other Neurotransmitters Small Molecule
Sabeluzole R58735 Alzheimer's Disease (Inactive) Unknown Small Molecule
Saracatinib AZD0530 Alzheimer's Disease (Phase 2) AstraZeneca Other Small Molecule
Sargramostim Leukine®,
GM-CSF
Alzheimer's Disease (Phase 2) Genzyme, Sanofi Inflammation, Other, Unknown Other Bone Marrow Stimulation
Semagacestat LY450139 Dihydrate ,
hydroxylvaleryl monobenzocaprolactam
Alzheimer's Disease (Discontinued) Eli Lilly & Co. Amyloid-Related Small Molecule None
Sembragiline RO4602522,
RG1577
Alzheimer's Disease (Discontinued) Evotech AG, Roche Other Neurotransmitters, Other Small Molecule
Simvastatin Zocor®,
Lipex®,
Lipovas®,
Denan®
Alzheimer's Disease (Inactive), Mild Cognitive Impairment (Phase 4) Merck Cholesterol Small Molecule Hypercholesterolemia and diabetic cardiomyopathy.
Solanezumab LY2062430 Alzheimer's Disease (Phase 3) Eli Lilly & Co. Amyloid-Related Immunotherapy (passive) None
Souvenaid FortasynTM Connect Alzheimer's Disease (Not Regulated) Other Dietary Supplement
Suritozole MD 26479 Alzheimer's Disease (Discontinued) Aventis Pharmaceuticals, Inc. (was Hoechst) Other Neurotransmitters Small Molecule
T3D-959 DB959 Alzheimer's Disease (Phase 2) T3D Therapeutics, Inc. Other Small Molecule
TPI 287 Alzheimer's Disease (Phase 1), Corticobasal Degeneration (Phase 1), Progressive Supranuclear Palsy (Phase 1) Cortice Biosciences Tau Small Molecule
Tacrine Cognex™ Alzheimer's Disease (Approved) Pfizer, Shionogi Pharma Cholinergic System Small Molecule
Telmisartan Micardis Alzheimer's Disease (Phase 2) Boehringer Ingelheim Other Small Molecule Hypertension
Thalidomide Thalomid® Alzheimer's Disease (Phase 2/3) Celgene Corporation Amyloid-Related, Inflammation Small Molecule
Tideglusib NP031112,
Nypta® ,
Zentylor™ ,
Glycogen synthase kinase 3 inhibitor,
NP12
Alzheimer's Disease (Discontinued), Progressive Supranuclear Palsy (Discontinued) Zeltia Group Tau Small Molecule
UB 311 Alzheimer's Disease (Phase 2) United Neuroscience Amyloid-Related Immunotherapy (active)
Valproate Depakote,
Depakene,
Valproic acid ,
Divalproex sodium
Alzheimer's Disease (Inactive) Abbott Laboratories Other Neurotransmitters Small Molecule Epilepsy, Bipolar disorder, Migraine
Vanutide cridificar ACC-001,
PF-05236806
Alzheimer's Disease (Discontinued) Janssen Amyloid-Related Immunotherapy (active) None
Varenicline Champix™,
Chantix™,
Varenicline tartrate,
CP-526,555,
Alpha4 beta2 nicotinic receptor agonist
Alzheimer's Disease (Discontinued) Pfizer Cholinergic System Small Molecule Smoking cessation
Verubecestat MK-8931, MK-8931-009 ,
BACE inhibitor
Alzheimer's Disease (Phase 3) Merck Amyloid-Related Small Molecule
Xaliproden SR 57746A Alzheimer's Disease (Discontinued) Sanofi Other Neurotransmitters, Other Small Molecule
XanamemTM UE 2343 Alzheimer's Disease (Phase 2) Actinogen Medical Other Small Molecule
Young Plasma Progressive Supranuclear Palsy (Phase 1), Alzheimer's Disease (Phase 1) Alkahest, Inc., Grifols Biologicals Inc. Inflammation, Other, Unknown Other