Therapeutics

PXT864

Overview

Name: PXT864
Synonyms: PXT00864
Therapy Type: Small Molecule (timeline)
Target Type: Other Neurotransmitters (timeline)
Condition(s): Alzheimer's Disease
U.S. FDA Status: Alzheimer's Disease (Phase 2)
Company: Pharnext

Background

PXT864 is an example of a repurposed drug combination. It uses baclofen and acamprosate, taken twice a day. Baclophen is a derivative of γ-aminobutyric acid, aka GABA, and acts as a GABA-B receptor agonist. It is used as a muscle relaxant to treat spasticity, for example in cerebral palsy and multiple sclerosis. Acamprosate is a drug of unclear mechanism of action, which is used to treat alcohol dependence. Pharnext claims that the low-dose combination of these two compounds, PXT864, is neuroprotective by way of restoring the brain’s balance between excitatory glutamatergic and inhibitory glycine and GABA activity, which in Alzheimer’s disease is disrupted by Aβ oligomers (Chumakov et al., 2015).

Combination therapy is widely seen to be necessary to achieve a large treatment benefit in AD. As of 2016, most such approaches use approved drugs, such as PXT864. No combination trials of two investigational medications have started (e.g., Feb 2013 newsJun 2015 news), though preclinical work is ongoing (see Jul 2014 news).

Findings

From February 2013 to June 2015, Pharnext ran PLEODIAL I, a Phase 2 study in Bordeaux and several other sites in France. It compared an eight-week course (four weeks treatment, four weeks washout, four more weeks of treatment) of PXT864 to placebo in 47 participants with mild Alzheimer's disease. The trial used three doses—0.4 mg acamprosate and 6 mg baclofen, 1 mg acamprosate and 15 mg baclofen, 20 mg acamprosate and 12 mg baclofen—with acamprosate and baclofen being taken as separate capsules twice daily. Primary endpoints included change from baseline in the ADAS-cog11 and adverse events; secondary outcomes included several cognitive, clinical, and global measures.

In addition, the trial used EEG measures of cognitive event-related potential (ERPs) as an ancillary outcome measure.  At the 2016 AAIC conference in Toronto, Pharnext collaborators reported that the cognitive ERP results indicated neurophysiological activity of PXT864 in three patients (see abstract).

From June 2013 to December 2015, Pharnext ran a six-month open-label extension trial of PXT864 for 45 people who had completed the PLEODIAL 1 trial. Here, too, ADAS-cog 11 and safety were the main outcomes. 

According to Pharnext's website, PXT864 is in Phase 1 for amyotrophic lateral sclerosis and Parkinson's disease, as well.

For all trials of PXT864, see clinicaltrials.gov.

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References

News Citations

  1. Combination Trials: Companies Can Play Well in One Sandbox
  2. Advisory Panel Grapples with Combination Therapy
  3. Anti-Amyloid Therapies Combine Forces to Knock Out Plaques

Other Citations

  1. Chumakov et al., 2015

External Citations

  1. abstract
  2. clinicaltrials.gov
  3. γ-aminobutyric acid

Further Reading

No Available Further Reading