Therapeutics

PRX-03140

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Overview

Name: PRX-03140
Synonyms: Potassium salt
Chemical Name: 7-isopropyl-6-oxo-5(3-piperidin-1-yl-propylcarbamoyl)-6,7-dihydro-thieno[2,3-b]pyridine-4-olate
Therapy Type: Small Molecule
Target Type: Other
Condition(s): Alzheimer's Disease
U.S. FDA Status: Alzheimer's Disease (Inactive)
Company: Epix Pharmaceuticals

Background

5-HT4 receptor agonists augment neuronal acetylcholine release (Ansanay et al., 1995; Torres et al., 1995) as well as modulate levels of Aβ and soluble amyloid precursor protein alpha (sAPPα) (Lezoualc’h & Robert., 2003; Robert et al., 2001).

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References

Paper Citations

  1. . cAMP-dependent, long-lasting inhibition of a K+ current in mammalian neurons. Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6635-9. PubMed.
  2. . Cyclic AMP and protein kinase A mediate 5-hydroxytryptamine type 4 receptor regulation of calcium-activated potassium current in adult hippocampal neurons. Mol Pharmacol. 1995 Jan;47(1):191-7. PubMed.
  3. . The serotonin 5-HT4 receptor and the amyloid precursor protein processing. Exp Gerontol. 2003 Jan-Feb;38(1-2):159-66. PubMed.
  4. . The human serotonin 5-HT4 receptor regulates secretion of non-amyloidogenic precursor protein. J Biol Chem. 2001 Nov 30;276(48):44881-8. PubMed.

Further Reading

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