Therapeutics

NeoTrofin

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Overview

Name: NeoTrofin
Synonyms: AIT-082, leteprinim
Chemical Name: 4-{[3-(6-oxo-3,6-dihydro-9H-purin-9-yl)propanoyl]amino}benzoic acid
Therapy Type: Small Molecule (timeline)
Target Type: Unknown
Condition(s): Alzheimer's Disease
U.S. FDA Status: Alzheimer's Disease (Discontinued)
Company: NeoTherapeutics, Inc.
Approved for: None

Background

NeoTrofin is a derivative of the purine hypoxanthin. It was found to stimulate the production mRNA for NGF, neurotrophin-3, and bFGF in cultured mouse astrocytes (Glasky et al., 1995). 

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