Therapeutics

Milameline

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Overview

Name: Milameline
Synonyms: CI 979
Therapy Type: Small Molecule (timeline)
Target Type: Cholinergic System (timeline)
Condition(s): Alzheimer's Disease
U.S. FDA Status: Alzheimer's Disease (Discontinued)
Company: Aventis Pharmaceuticals, Inc. (was Hoechst)
Approved for: None

Background

Milameline is a muscarinic receptor agonist with approximately equal affinities determined at the five subtypes of human muscarinic receptors (hM1–hM5) (Schwarz et al., 1999).

Last Updated: 12 Dec 2013

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References

Paper Citations

  1. Schwarz RD, Callahan MJ, Coughenour LL, Dickerson MR, Kinsora JJ, Lipinski WJ, Raby CA, Spencer CJ, Tecle H. Milameline (CI-979/RU35926): a muscarinic receptor agonist with cognition-activating properties: biochemical and in vivo characterization. J Pharmacol Exp Ther. 1999 Nov;291(2):812-22. PubMed.

Further Reading

No Available Further Reading