Synonyms: AZD-103, Scyllo-inositol, cyclohexane-1,2,3,4,5,6-hexol
Therapy Type: Small Molecule
Target Type: Amyloid-Related (timeline)
Condition(s): Alzheimer's Disease
U.S. FDA Status: Alzheimer's Disease (Phase 2)
Company: Elan Corporation, Speranza Therapeutics
Approved for: None
ELND005 is an inositol stereoisomer that is thought to neutralize toxic, low-N Aβ oligomers and prevent them from aggregating. It has been reported to lead to dose-dependent decreases in amyloid pathology, insoluble Aβ40 and Aβ42, and subsequent plaque accumulation in TgCRND8 mice. In vivo, the compound rescued Aβ-induced toxicity on synaptic transmission in mouse hippocampi and erased learning deficits in transgenic mice. The treatment appeared to work both when it was begun before symptoms appeared, and after the disease process was established. Beneficial effects via neuronal autophagy and preservation of choline acetyltransferase have also been proposed.
In Phase 1, a first study in eight healthy volunteers and a second, ascending-dose study in 13 healthy volunteers indicated that the treatment was safe and well-tolerated.
A Phase 2 trial in 353 patients with mild to moderate Alzheimer’s disease tested doses of 500, 2,000, and 4,000 mg/day taken for 18 months. Primary endpoints were the Neuropsychological Test Battery (NTB) and Alzheimer's Disease Cooperative Study-Activities of Daily Living (ADCS-ADL) scores. In June 2009, a long-term extension of this trial began, enrolling 150 patients who had completed the randomized part of the study. The primary endpoints of the study extension were safety, tolerability, and clinically important changes in laboratory assessments. The extension trial completed in mid-2011. After an interim analysis, in December 2009 investigators dropped the 2,000 or 4,000 mg/day doses in both the randomized study and the extension trial due to a higher number of serious adverse events seen in patients taking these doses. Besides an increased rate of infections, the adverse events included nine deaths, though they were never definitively linked to ELND005 (see Dec 2009 news story). The trial continued with 500 mg/day. Falls, depression, and confusion were the most common side effects at this dose, and the data safety monitoring committee deemed its tolerability to be acceptable. This Phase 2 study was negative on its primary endpoints of cognitive or functional improvement. At 500 mg/day, ELND005 did appear to reduce Aβ levels in a CSF substudy (see Salloway et al., 2011).
Prespecified subgroup analysis indicated that some patients on the low dose had improved on some neuropsychiatric measures, and Elan decided to continue to explore those. A new mechanism of action was proposed whereby ELND005, i.e. scylloinositol, lowers brain levels of its endogenous isoform myoinositol, and exerts effects similar to lithium in the treatment of bipolar disorder (see Jun 2012 conference story). In November 2012, Elan started a second Phase 2 trial, evaluating a single dose of ELND005 in 400 patients with moderate to advanced Alzheimer's for its effect on the agitation and aggression subscores in the Neuropsychiatric Inventory-Clinician rating scale (NPI-C). This is a 12-week trial with an 18-week safety extension. The FDA fast-tracked ELND005 for this indication in July 2013 (see company press release).
In 2012, Elan started a Phase 2 study of AZD-103 as an add-on therapy in 400 patients with bipolar disoreder, and in 2013, a Phase 2 trial began evaluating of AZD-103 in 24 young adults with Down’s syndrome. Results for both studies are expected in 2014. For all trials of this drug, see clinicaltrials.gov.
Clinical Trial Timeline
- Phase 2
- Study completed / Planned end date
- Planned end date unavailable
- Study aborted
- Drug Brief—Adverse Events Prompt Dose Drop in Elan Trial
- Stockholm: Therapeutics Roundup—Some New, Some Not So Much
- Salloway S, Sperling R, Keren R, Porsteinsson AP, van Dyck CH, Tariot PN, Gilman S, Arnold D, Abushakra S, Hernandez C, Crans G, Liang E, Quinn G, Bairu M, Pastrak A, Cedarbaum JM, . A phase 2 randomized trial of ELND005, scyllo-inositol, in mild to moderate Alzheimer disease. Neurology. 2011 Sep 27;77(13):1253-62. PubMed.
- Ma K, Thomason LA, McLaurin J. scyllo-Inositol, preclinical, and clinical data for Alzheimer's disease. Adv Pharmacol. 2012;64:177-212. PubMed.
- Lai AY, McLaurin J. Inhibition of amyloid-beta peptide aggregation rescues the autophagic deficits in the TgCRND8 mouse model of Alzheimer disease. Biochim Biophys Acta. 2012 Oct;1822(10):1629-37. PubMed.
- McLaurin J, Golomb R, Jurewicz A, Antel JP, Fraser PE. Inositol stereoisomers stabilize an oligomeric aggregate of Alzheimer amyloid beta peptide and inhibit abeta -induced toxicity. J Biol Chem. 2000 Jun 16;275(24):18495-502. PubMed.
- Sun Y, Zhang G, Hawkes CA, Shaw JE, McLaurin J, Nitz M. Synthesis of scyllo-inositol derivatives and their effects on amyloid beta peptide aggregation. Bioorg Med Chem. 2008 Aug 1;16(15):7177-84. PubMed.