Synonyms: diferuloylmethane, Longvida™
Chemical Name: (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
Therapy Type: Dietary Supplement
Target Type: Other, Unknown
Condition(s): Alzheimer's Disease
U.S. FDA Status: Alzheimer's Disease (Phase 2)
Company: Verdure Sciences
Approved for: None
Curcumin, the natural polyphenol that provides the yellow hue to turmeric, has been used in Indian Ayurvedic as well as traditional Chinese and Southeast Asian medicines for centuries to treat a wide variety of ailments. Animal models have demonstrated diverse beneficial effects of the compound, including anti-inflammatory and antioxidant properties as well as inhibiting Aβ aggregation (Yang et al., 2005). Curcumin is in clinical trials for various cognitive conditions, including AD and MCI.
Curcumin has many potentially neuroprotective properties. It is described as possessing anti-amyloid properties as well as acting as an antioxidant and anti-inflammatory compound (reviewed in Cole et al., 2007, and Frautschy and Cole, 2010). It has also been reported to promote metal chelation (Baum et al., 2004), inhibit tau aggregation (Frautschy and Cole, 2010) and promote neurogenesis (Begum et al., 2008; Kang et al., 2006).
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