Therapeutics

Clioquinol

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Overview

Name: Clioquinol
Synonyms: iodochlorhydroxyquin, PBT-1
Chemical Name: 5-chloro-7-iodo-quinolin-8-ol
Therapy Type: Small Molecule
Target Type: Metals
Condition(s): Alzheimer's Disease
U.S. FDA Status: Alzheimer's Disease (Discontinued)
Approved for: none

Background

Clioquinol was used for years as an antifungal and antibacterial medication, administered topically and/or orally. However, it was found to have neurotoxic effects, especially when used chronically at high doses. Topical clioquinol remains in clinical use for certain skin infections, such as ringworm. Despite its neurotoxicity, clioquinol has been explored at lower doses for possible beneficial effects due to its metal-chelating properties. Metal ions such as copper and zinc have been found to be associated with plaques and appear to facilitate plaque formation.

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Further Reading

Papers

  1. . Metal protein attenuating compounds for the treatment of Alzheimer's dementia. Cochrane Database Syst Rev. 2014 Feb 21;2:CD005380. PubMed.