Therapeutics

AADvac-1

Overview

Name: AADvac-1
Synonyms: Axon peptide 108 conjugated to KLH
Therapy Type: Immunotherapy (active) (timeline)
Target Type: Tau (timeline)
Condition(s): Alzheimer's Disease
U.S. FDA Status: Alzheimer's Disease (Phase 2)
Company: Axon Neuroscience SE

Background

This is an active vaccine designed to elicit an immune response against pathologically modified forms of tau protein. The approach was inspired by research on tau cleavage generating N-terminally truncated fragments (Feb 2013 newsPaholikova et al., 2015). 

The AADvac-1 vaccine consists of a synthetic peptide derived from amino acids 294 to 305 of the tau sequence, i.e., KDNIKHVPGGGS, coupled to keyhole limpet hemocyanin; the precise molecular nature of the antigen has not been disclosed. AADvac-1 uses aluminum hydroxide as an adjuvant. At the 2014 AAIC conference in Copenhagen, preclinical studies were reported as having met safety requirements for up to six months in rats, rabbits, and dogs; a paper reported that the vaccine reduced tau pathology and improved sensorimotor function in transgenic rats  (Aug 2014 newsKontsekova et al., 2014).

Findings

In May 2013, Axon Neuroscience began a first-in-man Phase 1 trial at three sites in Austria to evaluate AADvac-1 in 30 patients with mild to moderate Alzheimer’s disease. Three subcutaneous, monthly injections of a single dose were assessed for safety, tolerability, and immunogenicity; some exploratory assessment of cognition was also done. A three-month, double-blind, randomized phase was followed by another three months of open-label observation for a total of six injections. After that, patients could enroll in a follow-up study lasting a further 18 months.

At the July 2015 AAIC conference, the company announced results. Twenty-four patients had been randomized to AADvac-1, six to placebo, according to Reinhold Schmidt of University of Graz. Two withdrew due to adverse events, of which one—a viral infection followed by epileptic seizure—was considered to be possibly related to the study medication. Overall, AADvac-1 in this study was safe and well-tolerated, Schmidt said. In a majority of participants, the vaccine induced increasing antibody titers with repeat injections. Mean ADAS-cog scores remained stable over six months.

In March 2016, a 24-month Phase 2 safety trial in mild to moderate AD began to enroll 185 patients with mild to moderate AD and an MRI consistent with this diagnosis. This trial is not ascertaining the presence of amyloid or tau pathology at study entry. The study compares eight subcutaneous injections of 40 microgram of vaccine with the adjuvant aluminum hydroxide to placebo. The primary outcome is safety; secondary outcomes include cognitive and clinical batteries as well a measure of immunogenicity. FDG PET, MRI volumetry, and CSF biochemistry constitute exploratory outcomes. This study lists 30 exclusion criteria. It is being conducted in Austria, the Czech Republic, Slovakia, and Sweden, and slated to run until February 2019.

For details on AADvac-1 trials, see clinicaltrials.gov

Clinical Trial Timeline

  • Phase 1
  • Phase 2
  • Study completed / Planned end date
  • Planned end date unavailable
  • Study aborted
Sponsor Clinical Trial 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 2026 2027
Axon Neuroscience SE NCT01850238
N=30
Axon Neuroscience SE NCT02031198
N=30
Axon Neuroscience SE NCT02579252
N=185

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References

News Citations

  1. Truncated Tau Triggers Tangles, Transmits Pathology
  2. Therapies Take Aim at Tau

Paper Citations

  1. . N-terminal truncation of microtubule associated protein tau dysregulates its cellular localization. J Alzheimers Dis. 2015;43(3):915-26. PubMed.
  2. . First-in-man tau vaccine targeting structural determinants essential for pathological tau-tau interaction reduces tau oligomerisation and neurofibrillary degeneration in an Alzheimer's disease model. Alzheimers Res Ther. 2014;6(4):44. Epub 2014 Aug 1 PubMed.

External Citations

  1. clinicaltrials.gov

Further Reading

Papers

  1. . Who fans the flames of Alzheimer's disease brains? Misfolded tau on the crossroad of neurodegenerative and inflammatory pathways. J Neuroinflammation. 2012;9:47. PubMed.
  2. . The self-perpetuating tau truncation circle. Biochem Soc Trans. 2012 Aug;40(4):681-6. PubMed.
  3. . Misfolded truncated protein τ induces innate immune response via MAPK pathway. J Immunol. 2011 Sep 1;187(5):2732-9. PubMed.
  4. . Tau truncation is a productive posttranslational modification of neurofibrillary degeneration in Alzheimer's disease. Curr Alzheimer Res. 2010 Dec;7(8):708-16. PubMed.