Senile Plaque Imaging Study in Patients with Alzheimer's Disease Using
Positron Emission Tomography
Brief Description
This study takes place one time at the PET Centre located at the Centre
for Addiction and Mental Health Clarke site (Toronto, Canada). After
injecting the tracer (a chemical substance) via a vein in your arm, you
will lie down in the PET scanner for a maximum of 2 hours, as the PET
scan images the tracer as
it enters your brain. During this time, about 10 blood samples of 10 mL
each will be drawn from you via an IV. Thus, for those samples a needle
will be placed only once. Your caregiver may be present throughout the
study. You may take part in up to 3 PET studies using three different
beta-amyloid tracers. An honorarium for study participation will be
provided. This study has implications for early diagnosis of
Alzheimer's disease and for testing treatment interventions aimed at
preventing and/or slowing the progression of Alzheimer's disease.
Study Criteria (In order to qualify):
Participants must have:
An age of at least 18 years old
- A mini mental status exam score of less than 27
- A diagnosis of dementia of the Alzheimer's type (DSM-IV & NINCDS-ADRDA)
- No psychiatric disorders that cannot be attributed to Alzheimer's
dementia
- No serious medical or neurological illness or significant head injury
- No lifetime history of alcohol or substance dependence
- No alcohol or substance abuse in the past 6 months
Healthy control subjects must have:
- An age of at least 18 years old
- No cognitive, medical, neurological, or psychiatric problems.
- No history of psychotropic medication such as antidepressants,
antipsychotics, etc
- No lifetime history of alcohol or substance dependence
- No alcohol or substance abuse in the past 6 months
- No significant head injury
- Willingness to attend appointments reliably.
Ethical Review:
This study has received documented ethical approval from a research
ethics board or an institutional review board.
Contact Information
We ask that you print out this trial information and discuss it with
your family doctor or specialist prior to contacting the study
coordinator. Your doctor can help you understand the risks and benefits
of participating in this clinical trial.
Potential study volunteers should call as soon as possible:
Contact: Christina Pataky, Research Assistant
The Rotman Research Institute, Baycrest Centre for Geriatric
Care
Address: 3560 Bathurst Street, Toronto, Ontario, M6A 2E1, Canada
Phone: 416-785-2500-x 3363
Email: cpataky@rotman-baycrest.on.ca
Main Investigator: Nicolaas Paul L.G. Verhoeff, MD, PhD, FRCPC
|
Home
