10 RESULTS
COMMENT It is time for the Alzheimer’s field to abandon the "amyloid hypothesis" as a rigid model for developing treatment. The problem is that amyloid is not related to dementia—not temporally, pathologically, or therapeutically. Amyloid deposition ...
COMMENT The data presented in this paper provide strong evidence that doctors need to be aware of a patient's memory difficulties as soon as possible. A patient's memory is critical for two essential medical components: history taking and treatment ...
COMMENT The Stanford Neurology Department held a journal club meeting on this paper, conducted by Geoffery Kerchner, M.D. This meeting brought out some concern that several conclusions appear faulty, controls are missing, and the comparison datasets are not ...
COMMENT I have studied Alzheimer disease (AD) since 1978, and since about 1980, I have seen some new ideas for treating AD nearly every month. Of these, five have been FDA approved and have modest benefits for patients (some improvement in cognition and behavior, ...
COMMENT I have two comments that I still feel need to be clarified with respect to Dr. Small's presentation. 1. The difference between normal and pathological aging is artificial. As long as you are alive, you are surviving. When you are dead, it doesn' ...
COMMENT 1. I believe there is no evidence that any Alzheimer medication helps individuals without dementia. The MCI trials have been negative or showed a preponderance of adverse effects. Under normal and early AD circumstances, neurotransmitters in the brain are ...
COMMENT Alzheimer patients can be extremely difficult to treat. They can be very dangerous to the caregivers, not to mention the well-documented depression they cause in caregivers. I know that some clinicians do not think that antipsychotic medications are very ...
COMMENT This is an interesting paper coming from an excellent research group. I agree that neural networks and synaptic plasticity are at the center of Alzheimer disease (Ashford and Teter, 2002), but in interpreting the relevance of this study to AD, we should ...
COMMENT I think that this study is very interesting and well carried out. To some extent, this is an exciting new idea that could have a significant impact on the understanding of neurotransmission. It is clearly comparable to the exciting breakthroughs of the ...
COMMENT With reference to Alzheimer disease and memory mechanisms, this paper identifies 600 phosphorylation sites on synapses. Synapse formation and destruction are critical aspects of memory. Further, phosphorylation is a critical part of synaptic plasticity, ...
