44 RESULTS
COMMENT To further dissect the response to AD pathology, Hasselmann and collaborators used single-cell transcriptomic profiling and compared xenotransplanted microglia (xMG) isolated from aged control versus xMG from 5X-MITRG mice. Interestingly, xMG from both co
COMMENT Vascular abnormalities have been observed in dementia since the seminal studies of Alois Alzheimer and Oscar Fisher in the early 1900s. However, vascular abnormalities have often taken a back seat to the more prominent pathologies of amyloid plaques and n
COMMENT In this study, Shukla, Giniger and colleagues use fly genetics to show dysregulation of Cdk5 activity causes disruption of autophagy, a hyperactive innate immune response, and neurodegeneration of dopamine neurons in Drosophila. They elegantly demonstrate
COMMENT I think the RiboTag system is an elegant approach to profile ribosome-associated transcripts in a minimally invasive fashion as demonstrated by Kang et al. and other labs who have successfully applied the approach to study diverse microglia phenotypes (Ay
COMMENT This study is consistent with our previous work on the relationship of accumulation of DNA damage and neurodegeneration. In our paper published in 2013 in Nature Neuroscience (Wang et al.), we showed that the familial ALS gene product, FUS, a DNA/RNA bind
COMMENT Huang, Goate, and colleagues made remarkable findings that underscore the importance of noncoding genetic variation in regulation of gene expression relevant to disease. In particular, it highlights a function for the myeloid transcription factor PU.1 and
COMMENT We thank the commentators for taking the time to write about these findings and Alzforum for
COMMENT mechanisms, and provide new platforms for developing therapies. On Dr. Saido’s comments, I have the following
COMMENT This paper from Takaomi Saido and colleagues states that 60 percent of the phenotypes observed in the traditional AD mouse models are merely “artifacts” based on the absence of these phenotypes in their APP knock-in mouse models carrying two or three dist
COMMENT This study puts forth a novel strategy to treat the rare neurodegenerative disorder Niemann-Pick type C disease (NPC). This method utilizes a triple combination formulation of the HDAC inhibitor vorinostat, the lipid chelator 2-hydroxypropyl-β-cyclodextri
COMMENT In this study, the authors conducted an in-depth exploration of the Tet3 5-methylcytosine oxidase and reported a number of novel and exciting findings. They discovered that mammals possess three Tet3 isoforms, only one of which (Tet3FL) contains a chromat
COMMENT This is an interesting paper. I think the DNA damage response the authors report happens in a transient process, but prolonged activation of this DNA damage response may do more harm to cells. I like the aspect of phosphorylation of FAK by DNA-PK. We prev
COMMENT Histone deacetylases (HDACs) are increasingly recognized as playing important functions in learning and memory, and cumulative evidence suggests therapeutic applications of HDAC inhibitors (HDACis) for CNS disorders such as Rubinstein-Taybi syndrome and H
COMMENT Comment by Lily Y. Moy and Li-Huei Tsai A novel role for Cdk5 in dopaminergic neuronal loss has
COMMENT Tip60 is a histone acetyltransferase implicated in transcriptional activation and DNA repair. The intracellular domain generated from membranous cleavage of APP by γ-secretase is suggested to lead to activation of the transcriptional activity of Tip60 in
