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Grace Stutzmann on For Synapses, Are Aβ Oligomers a No-Go?

COMMENT Zhao et al. present an interesting study with a clearly presented mechanism proposing how exogenously applied ADDLs can result in synaptic decline via a reduction in Nogo-regulated spine assembly. This involves an inhibition of the low threshold, low ...

Peter Beal on Scientists Unleash CRISPR on RNA

COMMENT The novel feature of the Zhang system in the new Science paper is the use of a Cas protein/guide RNA complex for targeting specific RNA sequences. In other directed RNA-editing systems reported (i.e., from Joshua Rosenthal and Thorsten Stafforst labs), ...

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