Enza Maria Valente on PINK1 Caught on the Brink of Phosphorylation

COMMENT Among the proteins implicated in the pathogenesis of Parkinson’s disease, the mitochondrial kinase PINK1 is undoubtedly one of the most eclectic, and over the past decade it has been clearly demonstrated that its neuroprotective activity unravels through ...

Masayasu Okochi on Semagacestat, a Pseudo γ-Secretase Inhibitor?

COMMENT First, we would like to thank all the scientists and interviewees who made comments and gave their opinions on our study. These are very precious rewards for our efforts. In our previous Cell Reports paper (Okochi et al., 2013), we had started to confront ...

Xiao-Hong Lu on Scientists Unleash CRISPR on RNA

COMMENT To change the message: RNA editing for neurodegenerative disorders RNA has long been sought as a therapeutic target to provide transient amelioration of disease status without making permeant changes to the genetic markup. The recently reported RNA ...

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