Takaomi Saido on Time course of glucose metabolism in relation to cognitive performance and postmortem neuropathology in Met146Val PSEN1 mutation carriers.
COMMENT An important case study. 0 saido
219 RESULTS
COMMENT An important case study. 0 saido
COMMENT Whole-genome sequencing should be the one. 0 saido
COMMENT This is a very important study. 0 saido
COMMENT Interesting. 0 saido
COMMENT A very important and suggestive study. 0 saido
COMMENT A very indicative study. 0 saido
COMMENT Very important arguments. 0 saido
COMMENT Interesting. 0 saido
COMMENT Consistent with previous studies. 0 saido
COMMENT Mullan appears to misunderstand the architecture of modern biological science. Without the contributions by Glenner, Masters, Beyreuther, Van Broeckhoven, Hardy, Winblad, Lannfelt, and many others, the Swedish mutations would not have been identified. Wit
COMMENT This work is worth paying attention to. 0 saido
COMMENT Recommendable for all AD researchers. 0 saido
COMMENT This paper, together with previous ones, provides basic AD researchers with significant insights into future strategies. 0 saido
COMMENT The authors are well known for their sound experimental procedures. In this study, they crossbred Tg mice that overexpress APP and NEP. The transgene expression was driven by PDGF and CamKII promoters, respectively. This overexpression paradigm employed i
COMMENT A novel pharmacological target for prevention and treatment of AD. The authors' group previously demonstrated Aβ3(pE)-42 is approximately 250 times more prone to oligomerize than Aβ1-42. 0 saido On the seeding and oligomerization of pGlu-amyloid pe