396 RESULTS
COMMENT The issue of axonal transport in the context of ALS is relevant given the extreme polarization of motor neurons. Even subtle defects in transport would affect the delivery of cargo to (e.g., structural synaptic components, mitochondria, etc.) and transpor
COMMENT This is a well-performed study in part because the authors generated multiple iPSC lines from four ALS patients harboring different FUS mutations. More importantly, they generated one pair of isogenic lines with one corrected point mutation to confirm the
COMMENT Post-transcriptional regulation of gene expression is one of the determinants of cellular function and dysfunction. RNA deep sequencing data are often used as a proxy for gene expression regulation, however, in the majority of the cases the deduced analys
COMMENT The novel feature of the Zhang system in the new Science paper is the use of a Cas protein/guide RNA complex for targeting specific RNA sequences. In other directed RNA-editing systems reported (i.e., from Joshua Rosenthal and Thorsten Stafforst labs), ta
COMMENT I cannot comment on its usefulness or ease of use. Overall, the paper does represent a step forward in
COMMENT For over two decades, biomarker technology has been used in Alzheimer’s research. The ABIDE study is the first major project to explore the adoption of biomarker technology in clinical care of patients with mild cognitive impairment, and is therefore a ma
COMMENT This is a well-designed study to evaluate the risk of AD dementia and dementia in general in MCI patients, using biomarkers. The cohort of MCI patients was recruited from memory clinics and followed up to three years. Time-dependent analyses reveal the mu
COMMENT The papers by the Holtzman and Lamb groups describe how TREM2 plays a protective role in early disease by tamping down tau hyperphosphorylation and aggregation. The results imply that TREM2 normally protects against tau pathology. We would like to add ou
COMMENT Zhao et al. report an elegant series of experiments that elucidate mechanisms through which ApoE4 can interfere with brain insulin signaling. Their finding that ApoE4 impairs neuronal insulin signaling by binding to the insulin receptor, accelerating its
COMMENT Chronic hippocampal seizures impair cognition, an all-too-common biological comorbidity of temporal lobe epilepsy. What can be done? In the face of irreversible hippocampal cell loss followed by extensive structural rearrangements due to axonal sprouting,
COMMENT Rosshart et al. have made a great contribution to our understanding of the role of gut microbiome in determining disease phenotypes in mouse models. This work highlights the importance of reporting experimental details, and raises an issue that the field
COMMENT Our understanding of complex disorders has been immeasurably advanced with the use of model organisms such as mice. The use of inbred strains maintained under highly controlled conditions necessarily limits potential variables that typically confound in v
COMMENT In 1787, anatomist Paolo Mascagni published an atlas of all lymphatic vessels in the human body, which included the brain, where he described the presence of lymphatics in the cerebral dura mater (Mascagni, 1787, Vasorum Lymphaticorum Corporis Humani Hist
COMMENT This manuscript strengthens the data observed in rodents and described in Louveau et al. (2015). Using T2-FLAIR and T1-weighted black-blood imaging in humans and marmoset monkeys, the dural lymphatic vessels were observed in the present work bilaterally a
COMMENT This new paper on Alzheimer's disease relates pathogenesis to the aging-related, chronically decreasing ability of glucose to cross the blood-brain barrier. The bulk delivery of glucose through the blood-brain barrier is not insulin dependent. A mous
