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Lili Zhang on Semagacestat, a Pseudo γ-Secretase Inhibitor?

COMMENT Based on the observations that semagacestat inhibited only secreted Aβ but not intracellular or Aβ byproducts, Tagami, et al. suggested that semagacestat is only a “pseudo” γ-secretase inhibitor (GSI). However, an obvious alternative interpretation of ...

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