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Dominic Walsh on Role Reversal—AD Mouse Desperately Seeks CatB

COMMENT This is an extensive and very carefully controlled study in which the authors demonstrate that cathepsin B (CatB) can readily degrade Aβ in vivo and in vitro. At pH 6.0, CatB similarly degrades both non-aggregated and aggregated synthetic Aβ1-42, while at ...

Dominic Walsh on Atorvastatin, Vaccine Trial Data Published

COMMENT The analysis of a subset of patients for whom CSF samples were available before and after production of anti-Aβ antibodies suggests that successful immunization with Aβ may retard further neurodegeneration. Although the number of patients studied is very ...

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