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Robert Tycko on Amyloid-β Fibril Structure Bares All

COMMENT This is an important paper, demonstrating that detailed molecular structural information about Aβ fibrils can be obtained from cryoEM. Other labs have attempted this in earlier publications, but with less success. The success of this work by Gremer et al. ...

Robert Tycko on Will The Toxic Aβ Structure Please Stand Up?

COMMENT This paper from the Eisenberg group suggests several molecular structural models for fibrils formed by full-length β amyloid peptides, based on their crystal structures of segments of the full-length peptide that reveal the details of intermolecular ...

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