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Harald Steiner on Semagacestat, a Pseudo γ-Secretase Inhibitor?

COMMENT This is a very important paper, showing the unexpected result that semagacestat causes the accumulation of longer Aβ species and short peptide byproducts that are produced by the sequential carboxy-terminal trimming activity of γ-secretase. The paper ...

Harald Steiner on Pathogenic Presenilin Mutations Generate Aβ43

COMMENT One should add to the debate that the recent Chemuru et al., 2016, paper cited in Jie Shen and Ray Kelleher's comments as showing reduced amyloidogenicity of Aβ43 compared to Aβ42 is controversial. Another recent study, which was not cited, reported ...

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