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Takaomi Saido on Aβ Plaques: Breeding Ground for Toxic Tau?

COMMENT Based on pathological chronology and genetic evidence, I and others have postulated that Aβ is like the Mafia boss and tau is the hitman. The question is, how does Aβ amyloidosis induce tauopathy? In a previous study, a team led by Brad Hyman showed that ...

Takaomi Saido on Paper Alert: Aducanumab Phase 1b Study Published

COMMENT Scientists who have experience isolating Aβ from human brains may find the data shown in Figure 1 puzzling. Our lab has found Aβ deposits in human brain to be as hard as rocks. Because Aβ deposits resist such detergents as SDS, we usually depend on formic ...

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