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Takaomi Saido on Paper Alert: Aducanumab Phase 1b Study Published

COMMENT Scientists who have experience isolating Aβ from human brains may find the data shown in Figure 1 puzzling. Our lab has found Aβ deposits in human brain to be as hard as rocks. Because Aβ deposits resist such detergents as SDS, we usually depend on formic ...

Takaomi Saido on Aβ Oligomers Purified from Human Brain

COMMENT Although I did not attend the Zilkha Symposium, I would like point the audience's attention to a classic study by Yu-Min Kuo and Alex Roher, whose title was “Water-soluble Aβ (N-40, N-42) Oligomers in Normal and Alzheimer Disease Brains" (Kuo ...

Takaomi Saido on Pathogenic Presenilin Mutations Generate Aβ43

COMMENT The PS1 gene appears to be a FAD mutation hot spot: More than 200 mutations have been identified (PSEN1 mutations). Does anyone know why? The age of onset varies from 30 to 60. In comparison, the number of APP mutations is smaller (APP mutations), ...

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