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Lennart Mucke on Childhood Epilepsy Begets Adult Amyloid

COMMENT As recently reviewed in some depth (Palop and Mucke, 2016) and prospectively demonstrated in the clinic (Vossel et al., 2016), there clearly is an important link between Alzheimer’s disease and epilepsy, which may involve a vicious cycle between aberrant ...

Lennart Mucke on Enhancing Aβ Fibrillization Boosts Mouse Memory

COMMENT I appreciate Drs. Iijima and Iijima-Ando’s comments on our paper and would like to address a couple of points they raised. 1. “Why does the Arctic mutation cause FAD, if Aβ-Arctic is less toxic than wild-type Aβ (Aβ-Wt)?” Our study demonstrates that high ...

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