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Jochen Herms on Merck Pulls Plug on Phase 2/3 BACE Inhibitor Trial

COMMENT One should not forget that certain side effects of drugs that interfere with APP cleavage, like BACE inhibitors, affect synaptic plasticity and cognition in mice (Filser et al., 2015; Zhu et al., 2016). Of course we do not know if this holds true for ...

Jochen Herms on Alzheimer’s Disease: In the Eye of the Patient?

COMMENT We tried really hard to find any fibrillar Aβ plaques in the retina, both in humans and in various transgenic AD mouse models, but we failed to see what Koronyo et al. 2011 and 2012 had described. In our hands there is no fibrillar Aβ in the retina—which ...

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