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James Galvin on The AD8—Dementia Screen Ready for Prime Time?

COMMENT Reply to comment by Emory Hill The AD8 was designed as an informant assessment to screen for the presence of cognitive impairment of any cause. However, during its development, we also assessed whether in the absence of an informant, the AD8 would be ...

James Galvin on The cytoskeleton in neurodegenerative diseases.

COMMENT There has been, for obvious reasons, a tremendous research effort investigating the role of tau protein and synuclein protein as the building blocks for filaments in neruofibrillary tangles, Lewy bodies and glial cytoplasmic inclusions. However, it is ...

James Galvin on Alpha-synuclein and transgenic mouse models.

COMMENT The study of Lewy body disorders will be greatly advanced with the development and characterization of transgenic mouse models. Although most lines overexpress alpha-synuclein, not all lines have necessarily recapitulated LB-like pathology. It is also ...

James Galvin on Viral Transgene Models Parkinson's in Primate

COMMENT "A model, a model...my kingdom for a model!" At last, a model that appears to recapitulate not only some of the motor features of Parkinson's disease, but also the pathology. Even as we have come to understand the importance of α-synuclein ...

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