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Chris Exley on Notch Pathway Implicated in Multiple Sclerosis

COMMENT The two recent papers published in Science showing an apparent connection between A beta and tau pathologies in transgenic mice models are interesting. However, neither paper reports the effect of a positive control. In both cases a combination of two ...

Chris Exley on Fog Beginning to Clear on Aβ-Degrading Enzymes?

COMMENT This news report does not mention that the serine protease at the centre of the urokinase-plasminogen activator system, namely plasmin, is selective for Aβ 42 and in cleaving Aβ 42 prevents its aggregation into β-pleated sheet structures (see Exley and ...

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