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Martin Lavin on C9ORF72 Throws a Wrench into DNA Repair Machinery

COMMENT It is well established that DNA double-strand breaks and R-loops contribute to genome instability and, in turn, to pathological outcomes. What is novel about this study is that a mechanism is provided, bringing together both R-loops and DNA double-strand ...

Li-Huei Tsai on C9ORF72 Throws a Wrench into DNA Repair Machinery

COMMENT This study is consistent with our previous work on the relationship of accumulation of DNA damage and neurodegeneration. In our paper published in 2013 in Nature Neuroscience (Wang et al.), we showed that the familial ALS gene product, FUS, a DNA/RNA ...

Benjamin Wolozin on Tau Hooks Up with RNA to Form Droplets

COMMENT This work, from the laboratories of Ken Kosik and Songi Han, provides important new insight into the biology of tau protein. The manuscript builds on a growing body of work that is revolutionizing our knowledge of how proteins in the cell interact. For a ...

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