1380 RESULTS
CONFERENCE COVERAGE 2023-11-10 Conference Coverage While the trials, tribulations, and successes of Aβ immunotherapy were commanding Alzheimerologists' rapt attention, a different anti-amyloid approach has been quietly moving forward on the sidelines. PRI-002—a small molecule that
CONFERENCE COVERAGE 2023-11-09 Conference Coverage As the proteopathic drivers of Alzheimer's disease, Aβ and tau have for decades kept scientists trying to understand which of their isoforms and fragments are most to blame for the memory-robbing pathogenic cascade—and which ones
CONFERENCE COVERAGE 2023-11-08 Conference Coverage Some researchers have long argued for starting amyloid immunotherapy early, before tangles spread and neurons die all over the brain. At the 16th Clinical Trials on Alzheimer’s Disease conference, held October 24 to 27 in Boston and on
CONFERENCE COVERAGE 2023-11-05 Conference Coverage Evidence suggests that ethnoracial groups in the U.S. have different rates of age-related dementias, with Hispanic/Latino and black or African American people generally being more affected and Asian-Americans being less affected than w
CONFERENCE COVERAGE 2023-11-05 Conference Coverage Despite evidence that African American, Hispanic and Latino, and other minority groups have higher rates of Alzheimer’s and related dementias in the U.S., these populations are less likely to take part in clinical studies. This underre
CONFERENCE COVERAGE 2023-10-27 Conference Coverage Inflammation can be a helpful response to the common cold or the bite of an insect, but dangerous if it persists. In neurodegeneration, chronic micro- and astrogliosis spell trouble for the brain. Does it have to be that way? Over the
CONFERENCE COVERAGE 2023-10-21 Conference Coverage Since the 1990s, scientists have known cholesterol is important in Alzheimer's, but they gained little traction in their efforts to understand the relationship between the lipid and the disease. Though amyloid plaques, where the s
CONFERENCE COVERAGE 2023-10-20 Conference Coverage You might well think that myelin, the fatty insulation that speeds action potentials between neurons, falls solely under the purview of oligodendrocytes. After all, these specialized cells wrap cholesterol-laden myelin around axons in
CONFERENCE COVERAGE 2023-10-20 Conference Coverage Readers, ignore lipids at your peril. These oily molecules make up 60 percent of the human brain. Long considered mere wrapping for more interesting cellular contents, these fats hold secrets worth exploring. At the 2nd Symposium on Li
CONFERENCE COVERAGE 2023-08-25 Conference Coverage Almost everyone who has Down’s syndrome (DS) is fated to develop Alzheimer’s disease because they have three copies of the amyloid precursor protein (APP) gene. Their cells overproduce Aβ, they become amyloid- and tau-positive on PET b
CONFERENCE COVERAGE 2023-08-23 Conference Coverage Is a person born with APOE4 stuck with the lifelong consequences of this risk allele? These days, yes. In the future, perhaps not. APOE4 can be silenced, and the protective APOE2 allele introduced instead, according to Lance Johnson, U
CONFERENCE COVERAGE 2023-08-22 Conference Coverage In amyloid immunotherapy trials to date, biomarker change correlates with clinical efficacy, but the relationship is far from perfect. Plaque can fall and fluid biomarkers normalize without a statistically significant clinical benefit,
CONFERENCE COVERAGE 2023-08-22 Conference Coverage With three positive and three negative Phase 3 trials of second-generation anti-amyloid antibodies to draw upon, Alzheimerologists now have more data to mine for what works and what does not. At last month’s Alzheimer’s Association Int
CONFERENCE COVERAGE 2023-08-17 Conference Coverage Diagnostic criteria for Alzheimer’s disease were revised only five years ago, but the field has learned a lot since then. At the Alzheimer’s Association International Conference, held last month in Amsterdam, Clifford Jack of the Mayo
CONFERENCE COVERAGE 2023-08-15 Conference Coverage Scientists are a step closer to a diagnostic test for Lewy body disease. At AAIC2023, held July 16 to 20 in Amsterdam, Oskar Hansson, Lund University, Sweden, reported that an α-synuclein-based seed amplification assay identified peopl
