CONFERENCE COVERAGE 2007-04-04 Conference Coverage The science of frontotemporal dementias generated perhaps the loudest buzz at the 8th International Conference AD/PD 2007, held 14-18 March in Salzburg, Austria. The excitement grew out of last year’s twin discoveries that mutations in
CONFERENCE COVERAGE 2007-03-29 Conference Coverage Every other year, Abraham Fisher of the Israel Institute for Biological Research in Ness-Ziona, and Israel Hanin of Loyola University in Maywood, Illinois, team up with two local scientists from a different European country to host an
CONFERENCE COVERAGE 2007-03-13 Conference Coverage William Frey of the University of Minnesota in Minneapolis believes in the BBB. Rather than dealing with the pesky obstacle, though, he’s trying an end run around it. His route of choice is the nose, where his work suggests one gains a
CONFERENCE COVERAGE 2007-03-12 Conference Coverage When it comes to treating AD and other brain diseases, there is always something standing between the therapeutic pill and the cells needing help. That something is the blood-brain barrier (BBB), and it is a killing field of many a pro
CONFERENCE COVERAGE 2007-03-09 Conference Coverage With most drug discovery efforts ending in failure, all early-stage projects are by definition high-risk. The process of selecting candidates for advancement while mitigating that risk resembles natural selection as much as the competi
CONFERENCE COVERAGE 2007-03-08 Conference Coverage Judging by the growing number of academic centers that focus on screening or other phases of drug discovery, it might seem that universities ignore the mantra of “complement, don’t compete.” But they don’t, said Ross Stein, who directs
CONFERENCE COVERAGE 2007-03-07 Conference Coverage Researchers Huddle in Frigid New York New York felt like the windy city on February 5 and 6, when scientists gathered there for the conference on Drug Discovery for Neurodegenerative Disease. The 150 troupers who left their dens despit
CONFERENCE COVERAGE 2007-01-25 Conference Coverage By Jennifer Altman, based on her original report in Alzheimer Actualités, a newsletter published by the Ipsen Foundation. This report is part of the Alzforum Discussion Contemplating the Centennial. We thank the foundation for their pe
CONFERENCE COVERAGE 2007-01-04 Conference Coverage Drug discovery for neurodegenerative diseases continues on all fronts, from studies of fundamental biology to the development of new therapeutic compounds. The Cold Spring Harbor conference, Neurodegenerative Diseases: Biology and Ther
CONFERENCE COVERAGE 2007-01-03 Conference Coverage As the pipeline fills with potential therapies for Alzheimer (AD) and other neurodegenerative diseases, the research community is paying increased attention to how those therapies will be evaluated in clinical trials. Biomarkers, which
CONFERENCE COVERAGE 2006-11-20 Conference Coverage A lively platter of slide talks on APP processing and β-secretase (BACE) activities yielded a few interesting tidbits on the localization and regulation of β cleavage at this year’s annual meeting of the Society for Neuroscience in Atl
CONFERENCE COVERAGE 2006-11-16 Conference Coverage Everyone with even a passing interest in Alzheimer disease has seen a sepia-toned photograph of its namesake like the one on last week’s cover of Science magazine. A fatherly, pensive man with a mustache, sometimes a cigar, photographe
CONFERENCE COVERAGE 2006-11-16 Conference Coverage At this year’s annual meeting of the Society for Neuroscience, a grab bag of studies on the amyloid-β peptide highlighted some outstanding questions about the pesky fragment and its neurotoxic actions. What follows is just a brief flav
CONFERENCE COVERAGE 2006-11-14 Conference Coverage On Saturday, 3 November, 1906, Alois Alzheimer traveled from Munich, where he lived and worked, to Tuebingen. That afternoon, he was to address the 37th convention of Southwestern German psychiatrists, who were then called, cruelly, “I
CONFERENCE COVERAGE 2006-11-05 Conference Coverage This past August, Alzheimer disease researchers met with colleagues from other fields and with foundation and NIH representatives in Bar Harbor, Maine, at the sixth annual workshop on Enabling Technologies for Alzheimer Disease Researc