CONFERENCE COVERAGE 2023-08-04 Conference Coverage PET tracers that illuminate α-synuclein in the brain have been hard to come by, but scientists may be getting closer. According to a study published August 3 in Cell, an 18F- tracer developed at Emory University, Atlanta, binds to α-sy
CONFERENCE COVERAGE 2023-08-04 Conference Coverage When people think of early onset Alzheimer’s disease (EOAD), autosomal-dominant mutations in the APP or presenilin genes come to mind. But these account for fewer than 15 percent of EOAD cases. For the remainder, the Longitudinal Early
CONFERENCE COVERAGE 2023-08-01 Conference Coverage More than a decade before memory loss, fragments of phospho-tau start to rise in biofluids. These biomarkers, particularly p-tau217, have proven to be exquisite detectors of amyloid, but they plateau once symptoms surface and don’t tra
CONFERENCE COVERAGE 2023-07-29 Conference Coverage Scientists once hoped that blocking β-secretase would slow or prevent Alzheimer’s disease. Then came the rude awakening. The inhibitors caused the very thing they were supposed to prevent—cognitive decline. Enthusiasm tanked. Pharmaceu
CONFERENCE COVERAGE 2023-07-28 Conference Coverage Change was in the air at the Alzheimer’s Association International Conference, held July 16-20 in Amsterdam. With the first treatment in 20 years having just earned traditional approval from the U.S. Food and Drug Administration, anoth
CONFERENCE COVERAGE 2023-05-05 Conference Coverage With the emergence of COVID-19 three years in the past, the lingering neurological effects after initial illness remain nebulous. At the recent International Conference on Alzheimer’s and Parkinson’s Diseases in Gothenburg, Sweden, sci
CONFERENCE COVERAGE 2023-05-03 Conference Coverage Tau pathology is proving a tough nut to crack, with most antibodies directed against it posting negative results in clinical trials thus far. At the recent International Conference on Alzheimer’s and Parkinson’s Diseases in Gothenburg,
CONFERENCE COVERAGE 2023-05-02 Conference Coverage Do microglia thwart neurodegenerative disease, or help it along? Do they keep amyloid in check with one hand, while goading tau entanglement with the other? Do they protect neurons early on in disease, but sour into synaptic slayers la
CONFERENCE COVERAGE 2023-04-27 Conference Coverage After years of languishing in obscurity, the topic of disruptions in the brain's lipid metabolism is moving center stage. The number of publications in this area is growing, and at the International Conference on Alzheimer’s and P
CONFERENCE COVERAGE 2023-04-26 Conference Coverage Springing a leak is rarely good news, but when microglial mitochondria start oozing, it can be particularly bad in situations of tauopathy. So conclude scientists led by Li Gan and Sadaf Amin, Weill Cornell Medicine, New York, in the A
CONFERENCE COVERAGE 2023-04-25 Conference Coverage New data presented at the International Conference on Alzheimer’s and Parkinson’s Diseases, held March 28 to April 1 in Gothenburg, Sweden, further reinforced the field's growing recognition that microglia respond in myriad ways t
CONFERENCE COVERAGE 2023-04-25 Conference Coverage The scientific diet at this year’s International Conference on Alzheimer’s and Parkinson’s diseases, March 28 to April 1 in Gothenburg, was especially rich in news about the ins and outs of the microglial “gastrointestinal tract,” aka
CONFERENCE COVERAGE 2023-04-21 Conference Coverage Anti-amyloid immunotherapy has reached a milestone with the approval of two antibodies for clinical use; alas, the race is far from over. At the International Conference on Alzheimer’s and Parkinson’s Diseases, held March 28 to April 1
CONFERENCE COVERAGE 2023-04-21 Conference Coverage Seed amplification assays, those PCR-like reactions for toxic misfolded proteins, are starting to look pretty good. In the May Lancet Neurology, scientists led by Andrew Siderowf, University of Pennsylvania, Philadelphia, and Luis Conc
CONFERENCE COVERAGE 2023-04-20 Conference Coverage Retroviruses lurking in the human genome aren’t the only potential troublemakers in neurodegenerative diseases (see Part 5 of this series). Herpes simplex virus type 1 (HSV-1) integrates into the genome of trigeminal ganglia nerves, c