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RESEARCH NEWS 2024-01-24 Research News Researchers led by Nicholas Ashton at the University of Gothenburg, Sweden, recently reported that ALZpath Inc.’s plasma phospho-tau217 assay detected amyloid and tau positivity with 92 to 97 percent accuracy. Now, the data is peer-reviewed
RESEARCH NEWS 2024-01-24 Research News Cholesterol clears the brain once metabolized to 24-hydroxycholesterol, but that is not the only way 24HC can be beneficial, according to Silvia Maioli at the Karolinska Institutet in Stockholm. In the January 24 Science Advances, Maioli and
RESEARCH NEWS 2024-01-19 Research News When people come to their doctor with memory problems, they tend to want to know if Alzheimer's is to blame and, if so, what they can expect. Answering these questions with a degree of certainty is a tall order, and many view amyloid-PE
RESEARCH NEWS 2024-01-19 Research News The search for a good model of late-onset Alzheimer’s disease continues. Researchers led by Adrian Oblak of the Indiana University School of Medicine in Indianapolis and Gareth Howell at the Jackson Laboratory (JAX), Bar Harbor, Maine, have
RESEARCH NEWS 2024-01-17 Research News Most phospho-tau fluid biomarkers validated so far track more tightly with amyloid plaques than they do with tau tangles. A new study published January 6 in Acta Neuropathologica confirms that p-tau205 breaks that mold. In the cerebrospinal
RESEARCH NEWS 2024-01-17 Research News Some scientists believe that toxic tau fibrils hop between synapses to spread throughout the brain, prompted by Aβ aggregates and overactive neurons. New imaging and biomarker data add weight to this theory. In the January 3 Nature Communica
COMMUNITY NEWS 2024-01-12 Community News After decades of effort, setbacks, and dogged steps forward, Alzheimerologists breathed a collective sigh of relief last year with the U.S. FDA’s thumbs-up for Leqembi, the first traditional approval for a disease-modifying immunotherapy fo
RESEARCH NEWS 2024-01-05 Research News Neurons intertwine with small blood vessels in the brain, but how do the two communicate? With elaborate three-dimensional reconstructions of electron microscopy images, scientists led by Jie-Min Jia, Westlake University in Hangzhou, China,
RESEARCH NEWS 2024-01-05 Research News Health and lifestyle influence the risk of late-onset dementia. Is this true when disease begins before age 65? Yes, according to researchers led by Stevie Hendriks and Sebastian Köhler, Maastricht University, the Netherlands. In the Decembe
RESEARCH NEWS 2023-12-28 Research News Anyone on the heart failure drug Entresto who tests positive for Alzheimer’s disease based on blood Aβ42/40 might not want to panic. That’s because the drug can lower the amyloid ratio three times more than does brain amyloidosis. This is ac
RESEARCH NEWS 2023-12-27 Research News Although researchers know that most of the genetic risk for late-onset Alzheimer’s disease resides in microglia, exactly how these genes work their mischief remains something of a black box. In the November 29 Nature Communications, research
RESEARCH NEWS 2023-12-26 Research News Aggregation of Aβ throughout the neocortex is widely believed to unleash neurofibrillary tangles in the medial temporal lobe in people with AD. But what connects these two infamous proteopathic culprits in different regions of the brain? A s
RESEARCH NEWS 2023-12-22 Research News The picture of the mouse brain just got exponentially more complex. Using single-cell transcriptomics, epigenomics, and spatial genomics, scientists created an atlas of 32 million brain cells across all regions, distinguishing 5,300 cell typ
RESEARCH NEWS 2023-12-21 Research News Spatial transcriptomics may have just achieved single-cell resolution. Researchers led by Evan Macosko, Fei Chen, and colleagues at the Broad Institute in Cambridge, Massachusetts, bound together spatial gene expression and single-cell trans
CONFERENCE COVERAGE 2023-12-19 Conference Coverage At the second annual Holloway Summit, held November 30 to December 1 in Miami, frontotemporal dementia researchers showcased the current state of knowledge in finding biomarkers that identify different underlying pathologies of the dis
