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Different Cellular Mechanisms in Familial and Sporadic Alzheimer’s?

RESEARCH NEWS 2024-02-29 Research News How alike are familial and sporadic Alzheimer’s? It depends. Broadly speaking, in terms of their presymptomatic biomarker changes, the two resemble each other closely (see Feb 2024 news). In terms of what goes on inside affected cells, thing

No Loitering: Pathogenic Liaisons Trap TDP-43 in the Cytoplasm

RESEARCH NEWS 2024-02-29 Research News TDP-43 leads a varied life, interacting with a host of different RNAs and proteins as it shuttles from the nucleus to the cytoplasm and back. This offers this RNA-binding protein plenty of opportunities to take up with the wrong crowd. Case

While a Fly Sleeps, Its Glia Burn Neuronal Lipids to Refresh the Brain

RESEARCH NEWS 2024-02-27 Research News How does a good night’s sleep re-energize the brain? At least in fruit flies, by burning damaged lipids. So claim scientists led by Amita Sehgal at the University of Pennsylvania in Philadelphia. In the February 15 Nature Neuroscience, they

‛iNET’ Cultures Expose NPTX2 as TDP-43 Henchman

RESEARCH NEWS 2024-02-23 Research News The pathological accumulation of TDP-43 that underlies many cases of FTD, ALS, and LATE-NC has been notoriously difficult to recapitulate in mice or cultured human cells. In a paper published February 14 in Nature, scientists led by Magdalin

In Diabetes, Tight Blood Sugar Control Staves Off Dementia

RESEARCH NEWS 2024-02-21 Research News Type 2 diabetes (T2D) raises a person’s risk of developing dementia by about 50 percent. Does tightly controlling blood sugar decrease that risk? Yes, according to researchers led by Eng-Kiong Yeoh and Kailu Wang at the Chinese University of

Proteomics Uncovers Potential Markers of Early Autosomal Dominant AD

RESEARCH NEWS 2024-02-18 Research News Recent proteomic studies have offered glimpses into the biology of early Alzheimer’s disease. Two new preprints take this approach further, describing high-throughput surveys that turned up numerous new candidate biomarkers. In one, posted t

New U.K. Trials Network to Accelerate Dementia Studies

COMMUNITY NEWS 2024-02-16 Community News On January 24, the U.K.’s National Institute for Health and Care Research (NIHR) announced £49.9 million in funding to expand its Dementia Translational Research Collaboration (D-TRC) by creating a trials network led by Catherine Mummery of

Under the Radar: APP Uppsala Fibrils Evade Microglia, PiB, Leqembi

RESEARCH NEWS 2024-02-16 Research News Five years ago, scientists described a deletion of six amino acids within the APP gene, reporting that three members of a Swedish family, who each carried one copy of this “ Uppsala deletion,” developed Alzheimer’s disease in their early 40s

Meningeal Cuffs Around Veins Form Exit and Entry Ramps to the Brain

RESEARCH NEWS 2024-02-09 Research News Cerebrospinal fluid washes waste from the brain, eventually draining into the lymph nodes and bloodstream—but exactly how this flow bypasses the brain’s barriers to reach the periphery has remained somewhat mysterious. In the February 7 Natu

First Whole-Genome Sequencing of PSP Nets Six New Risk Loci

RESEARCH NEWS 2024-02-08 Research News Progressive supranuclear palsy, a rare tauopathy, slowly destroys a person's cognition, balance, and movement. PSP ranks second behind Parkinson’s disease as a cause of Parkinsonism. Beyond variants in the tau gene, a handful of other r

Moving Alzheimer’s Diagnosis to Primary Care Could Ease Bottlenecks

COMMUNITY NEWS 2024-02-06 Community News As more people in the U.S. seek treatment with the anti-amyloid antibody Leqembi, dementia clinics are becoming swamped, and wait times are lengthening (Jan 2024 news). Many clinicians believe that at least some aspects of diagnosis and tre

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