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Treating Tau: Finally, Clinical Candidates Are Stepping into the Ring

CONFERENCE COVERAGE 2017-04-27 Conference Coverage While many of the more advanced Alzheimer’s therapies currently in trials target amyloid, tau-based approaches are stepping up to the plate. At the 13th International Conference on Alzheimer’s and Parkinson’s Diseases, held March 29 to ...

Transcranial Magnetic Stimulation for AD Boasts Success in Phase 3

CONFERENCE COVERAGE 2017-04-27 Conference Coverage In Alzheimer’s disease, synaptic activity goes haywire and brain networks gradually falter. This has made some researchers wonder if externally stimulating brain activity could help people with the disease function better for a while. ...

Look in the MiR: MicroRNA Fans Neurogenesis in Old Alzheimer’s Mice

CONFERENCE COVERAGE 2017-04-26 Conference Coverage Tiny they may be, but don’t let their size fool you. At only 21-23 nucleotides in length, microRNAs orchestrate grand biological processes, and researchers are just starting to get a sense of their complex roles in neurodegenerative ...

NIH Summit Examines What Makes a Healthy Aging Brain

CONFERENCE COVERAGE 2017-04-25 Conference Coverage Neurodegenerative disease researchers spend a lot of time considering what goes wrong in the brain. But what about when things go right? Factors that contribute to healthy brain aging took center stage at the Cognitive Aging Summit ...

Location, Conformation, Decoration: Tau Biology Dazzles at AD/PD

CONFERENCE COVERAGE 2017-04-21 Conference Coverage The well of tau is in no danger of running dry, if findings presented at the 13th International Conference on Alzheimer’s and Parkinson’s Diseases, held March 29 to April 2 in Vienna, are any gauge. If anything, it was bubbling over as ...

New Evidence Confirms TREM2 Binds Aβ, Drives Protective Response

CONFERENCE COVERAGE 2017-04-19 Conference Coverage Variants in the microglial receptor TREM2 heighten the risk for neurodegeneration, though exactly how they do that has remained unclear as initial research produced conflicting results. Now, however, researchers appear to be reaching a ...

ApoE and Tau: Unholy Alliance Spawns Neurodegeneration

CONFERENCE COVERAGE 2017-04-15 Conference Coverage ApoE4 doesn’t need to interact with Aβ to wreak havoc in the brain. Tau tangles can bring out the apolipoprotein’s bad side too, according to findings presented at the 13th International Conference on Alzheimer’s and Parkinson’s ...

Are CSF Assays Finally Ready for Prime Time?

CONFERENCE COVERAGE 2017-04-15 Conference Coverage This story was updated on 18 April 2017 to correct an error. Cerebrospinal fluid biomarkers of Alzheimer’s disease have transformed clinical research, but transferring this technology to the clinic has not been easy. Even after intense ...

Next-Generation Tau PET Tracers Strut Their Stuff

CONFERENCE COVERAGE 2017-04-14 Conference Coverage The current crop of tau PET tracers have yielded new insights into the progression of Alzheimer’s disease, but they are plagued by problems. At the 13th International Conference on Alzheimer’s and Parkinson’s Diseases, held March 29 to ...

After Solanezumab: Where Should Alzheimer’s Research Go?

CONFERENCE COVERAGE 2017-01-31 Conference Coverage At a postmortem discussion for solanezumab therapy in mild Alzheimer’s disease, held January 19 in London, members of the top echelons of AD research in the UK and other countries discussed CSF biomarker data from the Expedition 3 ...

Emerging Alzheimer’s Therapies Test the Waters at CTAD

CONFERENCE COVERAGE 2016-12-30 Conference Coverage Beyond keynote speeches and eagerly awaited immunotherapy data, many presentations at the Clinical Trials on Alzheimer’s Disease (CTAD) conference, held December 8-10 in San Diego, detailed findings from therapies in the earliest ...

Tau-PET in Down’s: Unique Patterns Among Alzheimer’s Types and Stages

CONFERENCE COVERAGE 2016-12-22 Conference Coverage By the time memory frays, the brains of people with Alzheimer’s disease are already infested with Aβ plaques, but the growth of tau tangles tracks with worsening symptoms. With tau PET, researchers now have a tool to watch this happen, ...

Much ‘Adu’ About a Little: Phase 1 Data Feeds the Buzz at CTAD

CONFERENCE COVERAGE 2016-12-21 Conference Coverage Let down by solanezumab ’s demise, researchers at the Clinical Trials for Alzheimer’s Disease conference, held December 8-10 in San Diego, were in sore need of some good news. They got a taste of it, albeit small, with the release of ...

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