sAPP Binds GABA Receptor, and More News on APP

CONFERENCE COVERAGE 2017-07-21 Conference Coverage Researchers convened last month in Heidelberg, Germany, could have been forgiven for thinking they had been teleported back to AD research of the 1990s. Classic, good old biochemistry captured the limelight at Mechanisms in ...

Alzheimer’s Proteomics Treasure Trove?

CONFERENCE COVERAGE 2017-07-20 Conference Coverage The Alzheimer’s disease proteome has remained mostly a mystery. At the EMBO/EMBL Symposium on Mechanisms of Neurodegeneration, held June 14-17 in Heidelberg, Germany, Nick Seyfried described one of the first major attempts to chart ...

A New Explanation for Dendritic Tau: It’s Made There

CONFERENCE COVERAGE 2017-07-14 Conference Coverage In Alzheimer’s disease, the axonal protein tau accumulates aberrantly in dendritic spines, where it contributes to excitotoxicity. What causes this mislocalization? Previous studies have linked hyperphosphorylation or overexpression of ...

Microglial Regulation and Function Scrutinized at Heidelberg Meeting

CONFERENCE COVERAGE 2017-07-08 Conference Coverage New insights into microglial biology and function created quite the buzz at Mechanisms of Neurodegeneration, an EMBO/EMBL symposium held June 14-17. Organized by Karin Dumstrei, Todd Golde, Christian Haass, and Bart De Strooper, the ...

Protein Liquid-Liquid Phase Transitions: The Science Is About to Gel

CONFERENCE COVERAGE 2017-05-31 Conference Coverage The list of mammalian proteins capable of forming liquid droplets is growing by leaps and bounds. What does this say about human biology, and what does it mean for neurodegenerative diseases, which have been tied to this phenomenon? At ...

Anti-Amyloid Drug Pipeline Shows No Sign of Drying Up

CONFERENCE COVERAGE 2017-05-12 Conference Coverage Despite the litany of failed Alzheimer’s drugs, academic and industry researchers at the 13th International Conference on Alzheimer’s and Parkinson’s Diseases, held March 29 to April 2 in Vienna, appeared confident that they are moving ...

Non-Amyloid Treatments: Inflammation, Epigenetics, Regeneration

CONFERENCE COVERAGE 2017-05-11 Conference Coverage Alzheimer’s researchers are pursuing treatments beyond amyloid and tau, and at the 13th International Conference on Alzheimer’s and Parkinson’s Diseases, held March 29 to April 2 in Vienna, they shared news on drugs in Phase 1 and 2 ...

Do Smartphones Collect Better Clinical Data Than Paper-and-Pencil Tests?

CONFERENCE COVERAGE 2017-05-06 Conference Coverage Potential disease-modifying therapies are entering trials for Parkinson’s disease even as researchers need better biomarkers to track clinical improvement. Some believe that smartphones might hold the key. At the 13th International ...

α-Synuclein Antibodies Enter Phase 2, Sans Biomarker

CONFERENCE COVERAGE 2017-05-06 Conference Coverage In the search for ways to slow down the progression of Parkinson’s disease, researchers currently have α-synuclein in their crosshairs. A handful of approaches are in development, and immunotherapy strategies are now advancing through ...

Treating Tau: Finally, Clinical Candidates Are Stepping into the Ring

CONFERENCE COVERAGE 2017-04-27 Conference Coverage While many of the more advanced Alzheimer’s therapies currently in trials target amyloid, tau-based approaches are stepping up to the plate. At the 13th International Conference on Alzheimer’s and Parkinson’s Diseases, held March 29 to ...

Transcranial Magnetic Stimulation for AD Boasts Success in Phase 3

CONFERENCE COVERAGE 2017-04-27 Conference Coverage In Alzheimer’s disease, synaptic activity goes haywire and brain networks gradually falter. This has made some researchers wonder if externally stimulating brain activity could help people with the disease function better for a while. ...

Look in the MiR: MicroRNA Fans Neurogenesis in Old Alzheimer’s Mice

CONFERENCE COVERAGE 2017-04-26 Conference Coverage Tiny they may be, but don’t let their size fool you. At only 21-23 nucleotides in length, microRNAs orchestrate grand biological processes, and researchers are just starting to get a sense of their complex roles in neurodegenerative ...

NIH Summit Examines What Makes a Healthy Aging Brain

CONFERENCE COVERAGE 2017-04-25 Conference Coverage Neurodegenerative disease researchers spend a lot of time considering what goes wrong in the brain. But what about when things go right? Factors that contribute to healthy brain aging took center stage at the Cognitive Aging Summit ...

Location, Conformation, Decoration: Tau Biology Dazzles at AD/PD

CONFERENCE COVERAGE 2017-04-21 Conference Coverage The well of tau is in no danger of running dry, if findings presented at the 13th International Conference on Alzheimer’s and Parkinson’s Diseases, held March 29 to April 2 in Vienna, are any gauge. If anything, it was bubbling over as ...

New Evidence Confirms TREM2 Binds Aβ, Drives Protective Response

CONFERENCE COVERAGE 2017-04-19 Conference Coverage Variants in the microglial receptor TREM2 heighten the risk for neurodegeneration, though exactly how they do that has remained unclear as initial research produced conflicting results. Now, however, researchers appear to be reaching a ...

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