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High-Dose Aβ and Tau Immunotherapies Complete Initial Safety Tests

CONFERENCE COVERAGE 2017-08-27 Conference Coverage Part 3 of a three-part story. Since Aβ passive immunotherapy emerged as a potential treatment for Alzheimer’s disease, drug developers have struggled with a major challenge—how to get enough antibody into the brain to have the desired ...

At AAIC, Yet Another Phase 3 Flop While Phase 1 Trials Forge Ahead

CONFERENCE COVERAGE 2017-08-25 Conference Coverage Part 1 of a three-part story. At this year’s Alzheimer's Association International Conference, held July 16–20 in London, researchers reported negative data from three Phase 3 trials of the 5HT6 antagonist idalopirdine. It came as ...

Teasing Out the Brain Features Behind Cognitive Reserve

CONFERENCE COVERAGE 2017-08-25 Conference Coverage Some older adults maintain good memory and cognitive skills even in the face of extensive amyloid and tau pathology in the brain. This resilience has been dubbed “cognitive reserve,” but researchers still do not know exactly what ...

Longitudinal Data Say: Nope, CSF Markers Do Not Track Progression

CONFERENCE COVERAGE 2017-08-23 Conference Coverage Part 2 of a two-part story. As longitudinal biomarker data begin to roll in, they challenge some previous assumptions about Alzheimer’s disease progression. Researchers at the Alzheimer’s Association International Conference 2017, held ...

Data from DIAN Revise Familiar Biomarker Trajectories

CONFERENCE COVERAGE 2017-08-22 Conference Coverage Part 1 of a two-part story. As researchers analyze data in longitudinal biomarker studies, they find that some previously estimated biomarker trajectories do not hold up. At the Alzheimer’s Association International Conference 2017, ...

New Ties between AD and the Stages, Waves, and Molecules of Sleep

CONFERENCE COVERAGE 2017-08-17 Conference Coverage At the Alzheimer’s Association International Conference 2017 held in London July 16-20, the relationship between disturbed sleep and AD came into sharper focus. Scientists revealed how sleep-disordered breathing boosts the risk for ...

All Signs Point to Tau Tangles as the Culprit in Fading Memory

CONFERENCE COVERAGE 2017-08-12 Conference Coverage Part 2 of a two-part story. Click here for Part 1. The two hallmark pathologies of Alzheimer’s disease, amyloid plaques and tau tangles, play different roles in disease progression. Accumulating research suggests that amyloid plaques ...

CSF and Brain Markers Highlight Different Facets of Dementia

CONFERENCE COVERAGE 2017-08-12 Conference Coverage Part 1 of a two-part story. Click here for Part 2. While biomarkers have opened a window onto Alzheimer’s pathogenesis, the view has remained cloudy. At the Alzheimer’s Association International Conference 2017 held July 16-20 in ...

Lancet Commission Claims a Third of Dementia Cases Are Preventable

CONFERENCE COVERAGE 2017-08-11 Conference Coverage Spurred by the 2013 G8 Dementia Summit in London and by the First WHO Ministerial Conference on Global Action Against Dementia in March 2015, The Lancet commissioned an expert project to review available evidence and recommend how best ...

New Dementia Trials to Test Lifestyle Interventions

CONFERENCE COVERAGE 2017-08-11 Conference Coverage Hoping to stem the growing worldwide burden of dementia, scientists at the Alzheimer’s Association International Conference 2017 held in London July 16–20 described new studies to test whether multidomain lifestyle interventions can ...

Planning the First Primary Prevention Trial for Alzheimer’s Disease

CONFERENCE COVERAGE 2017-08-07 Conference Coverage Is it time for the first primary prevention trial for Alzheimer’s pathology? Observational studies have made clear that amyloid accumulation begins more than two decades before symptoms appear, creating a huge window for intervention. ...

Monomeric Seeds and Oligomeric Clouds—Proteopathy News from AAIC

CONFERENCE COVERAGE 2017-08-07 Conference Coverage Researchers studying protein aggregation have long debated two questions: What is the smallest structure than can seed different protein aggregates, aka strains, and how many different strains form within a brain? Researchers answered ...

Searching for New AD Risk Variants? Move Beyond GWAS

CONFERENCE COVERAGE 2017-08-04 Conference Coverage Geneticists continue to plumb the genome for clues to AD risk. New variants presented at this year’s Alzheimer’s Association International Conference, held in London July 16-20, reinforce the central role of microglia in AD and link ...

In Clinical Use, Amyloid Scans Change Two-Thirds of Treatment Plans

CONFERENCE COVERAGE 2017-08-01 Conference Coverage Brain amyloid imaging has become an essential tool for Alzheimer’s research, but the technology has not yet proved its value in clinical practice. Several studies are underway to investigate this. Chief among these is the massive ...

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