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Emerging Alzheimer’s Therapies Test the Waters at CTAD

CONFERENCE COVERAGE 2016-12-30 Conference Coverage Beyond keynote speeches and eagerly awaited immunotherapy data, many presentations at the Clinical Trials on Alzheimer’s Disease (CTAD) conference, held December 8-10 in San Diego, detailed findings from therapies in the earliest ...

Tau-PET in Down’s: Unique Patterns Among Alzheimer’s Types and Stages

CONFERENCE COVERAGE 2016-12-22 Conference Coverage By the time memory frays, the brains of people with Alzheimer’s disease are already infested with Aβ plaques, but the growth of tau tangles tracks with worsening symptoms. With tau PET, researchers now have a tool to watch this happen, ...

Much ‘Adu’ About a Little: Phase 1 Data Feeds the Buzz at CTAD

CONFERENCE COVERAGE 2016-12-21 Conference Coverage Let down by solanezumab ’s demise, researchers at the Clinical Trials for Alzheimer’s Disease conference, held December 8-10 in San Diego, were in sore need of some good news. They got a taste of it, albeit small, with the release of ...

Tau Inhibitor Fails Again—Subgroup Analysis Irks Clinicians at CTAD

CONFERENCE COVERAGE 2016-12-16 Conference Coverage The first oral communication session at this year’s Clinical Trials on Alzheimer’s Disease meeting (CTAD), held December 8-10 in San Diego, opened on a surreal note. Lon Schneider, University of Southern California, Los Angeles, first ...

CTAD: Solanezumab Seen to Nudge AD Ever so Slightly

CONFERENCE COVERAGE 2016-12-15 Conference Coverage Presenting the most eagerly awaited data at this year’s Clinical Trials on Alzheimer’s Disease meeting (CTAD) held December 8-10 in San Diego, Lawrence Honig, Columbia University, New York, reported that the Expedition 3 Phase 3 trial ...

Inflammation Helps Microglia Clear Amyloid from AD Brains

CONFERENCE COVERAGE 2016-12-09 Conference Coverage Neuroinflammation can both help and harm the Alzheimer’s brain, leaving researchers uncertain of the best way to modulate the immune system therapeutically. Previously, many scientists thought that dialing down inflammation would help, ...

Next-Generation Mouse Models: Tau Knock-ins and Human Chimeras

CONFERENCE COVERAGE 2016-12-08 Conference Coverage Scientists seeking better mouse models for Alzheimer’s disease recently developed human mutant APP knock-ins (see related SfN story). The slowly developing pathology in these mice may better resemble what happens in human brain, where ...

Knock-In Alzheimer’s Mice Catch on More Broadly in the Field

CONFERENCE COVERAGE 2016-12-08 Conference Coverage Scientists agree that mouse models of Alzheimer’s only partially recapitulate the disease and, more ominously, that their strong overexpression of human AD genes renders them prone to artifacts. In 2014, the group of Takaomi Saido of ...

Astrocytes and Exosomes Implicated in Protein Propagation

CONFERENCE COVERAGE 2016-12-07 Add Private note Add An editorial note Conference Coverage Many researchers now believe that misfolded proteins spread from cell to cell across the brain, corrupting normal proteins as they go, yet exactly how this propagation would happen remains unclear ...

Will Next-Gen BACE Inhibitors Dodge Side Effects?

CONFERENCE COVERAGE 2016-11-03 Add Private note Add An editorial note Conference Coverage While BACE inhibitor trials are unfolding, more than 100 experts in the field gathered for the 2nd Kloster Seeon Meeting on BACE Proteases in Health and Disease, held September 25-27 near Munich. ...

Does BACE Drive Neurites into Dystrophy, Shorting Circuits?

CONFERENCE COVERAGE 2016-10-31 Conference Coverage Beta-secretase inhibitors are a leading therapeutic strategy being evaluated for Alzheimer’s disease, but as scientists discussed last month at the 2nd Kloster Seeon meeting on BACE Proteases in Health and Disease, there is still much ...

BACE Inhibition and the Synapse—Insights from Seeon

CONFERENCE COVERAGE 2016-10-28 Add Private note Add An editorial note Conference Coverage Potential side effects remain a major concern for BACE inhibitor programs. Knocking out the gene for BACE1 in mice causes a variety of troubling phenotypes, not least being brain seizures (see ...

What Exactly Does BACE Do in Adults?

CONFERENCE COVERAGE 2016-10-27 Add Private note Add An editorial note Conference Coverage The 2nd Kloster Seeon Meeting on BACE Proteases in Health and Disease, held September 25-27 in Seeon near Munich, was propelled on an updraft of optimism that BACE inhibitors may work out to treat ...

At 2nd Kloster Seeon Meeting, Renewed Optimism for Targeting BACE1

CONFERENCE COVERAGE 2016-10-22 Add Private note Add An editorial note Conference Coverage More than 100 BACE aficionados gathered September 25 near Munich for the 2nd Kloster Seeon Meeting on BACE Proteases in Health and Disease. Organized by Stefan Lichtenthaler, German Center for ...

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