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Protein Liquid-Liquid Phase Transitions: The Science Is About to Gel

CONFERENCE COVERAGE 2017-05-31 Conference Coverage The list of mammalian proteins capable of forming liquid droplets is growing by leaps and bounds. What does this say about human biology, and what does it mean for neurodegenerative diseases, which have been tied to this phenomenon? At ...

Anti-Amyloid Drug Pipeline Shows No Sign of Drying Up

CONFERENCE COVERAGE 2017-05-12 Conference Coverage Despite the litany of failed Alzheimer’s drugs, academic and industry researchers at the 13th International Conference on Alzheimer’s and Parkinson’s Diseases, held March 29 to April 2 in Vienna, appeared confident that they are moving ...

Non-Amyloid Treatments: Inflammation, Epigenetics, Regeneration

CONFERENCE COVERAGE 2017-05-11 Conference Coverage Alzheimer’s researchers are pursuing treatments beyond amyloid and tau, and at the 13th International Conference on Alzheimer’s and Parkinson’s Diseases, held March 29 to April 2 in Vienna, they shared news on drugs in Phase 1 and 2 ...

Do Smartphones Collect Better Clinical Data Than Paper-and-Pencil Tests?

CONFERENCE COVERAGE 2017-05-06 Conference Coverage Potential disease-modifying therapies are entering trials for Parkinson’s disease even as researchers need better biomarkers to track clinical improvement. Some believe that smartphones might hold the key. At the 13th International ...

α-Synuclein Antibodies Enter Phase 2, Sans Biomarker

CONFERENCE COVERAGE 2017-05-06 Conference Coverage In the search for ways to slow down the progression of Parkinson’s disease, researchers currently have α-synuclein in their crosshairs. A handful of approaches are in development, and immunotherapy strategies are now advancing through ...

Treating Tau: Finally, Clinical Candidates Are Stepping into the Ring

CONFERENCE COVERAGE 2017-04-27 Conference Coverage While many of the more advanced Alzheimer’s therapies currently in trials target amyloid, tau-based approaches are stepping up to the plate. At the 13th International Conference on Alzheimer’s and Parkinson’s Diseases, held March 29 to ...

Transcranial Magnetic Stimulation for AD Boasts Success in Phase 3

CONFERENCE COVERAGE 2017-04-27 Conference Coverage In Alzheimer’s disease, synaptic activity goes haywire and brain networks gradually falter. This has made some researchers wonder if externally stimulating brain activity could help people with the disease function better for a while. ...

Look in the MiR: MicroRNA Fans Neurogenesis in Old Alzheimer’s Mice

CONFERENCE COVERAGE 2017-04-26 Conference Coverage Tiny they may be, but don’t let their size fool you. At only 21-23 nucleotides in length, microRNAs orchestrate grand biological processes, and researchers are just starting to get a sense of their complex roles in neurodegenerative ...

NIH Summit Examines What Makes a Healthy Aging Brain

CONFERENCE COVERAGE 2017-04-25 Conference Coverage Neurodegenerative disease researchers spend a lot of time considering what goes wrong in the brain. But what about when things go right? Factors that contribute to healthy brain aging took center stage at the Cognitive Aging Summit ...

Location, Conformation, Decoration: Tau Biology Dazzles at AD/PD

CONFERENCE COVERAGE 2017-04-21 Conference Coverage The well of tau is in no danger of running dry, if findings presented at the 13th International Conference on Alzheimer’s and Parkinson’s Diseases, held March 29 to April 2 in Vienna, are any gauge. If anything, it was bubbling over as ...

New Evidence Confirms TREM2 Binds Aβ, Drives Protective Response

CONFERENCE COVERAGE 2017-04-19 Conference Coverage Variants in the microglial receptor TREM2 heighten the risk for neurodegeneration, though exactly how they do that has remained unclear as initial research produced conflicting results. Now, however, researchers appear to be reaching a ...

ApoE and Tau: Unholy Alliance Spawns Neurodegeneration

CONFERENCE COVERAGE 2017-04-15 Conference Coverage ApoE4 doesn’t need to interact with Aβ to wreak havoc in the brain. Tau tangles can bring out the apolipoprotein’s bad side too, according to findings presented at the 13th International Conference on Alzheimer’s and Parkinson’s ...

Are CSF Assays Finally Ready for Prime Time?

CONFERENCE COVERAGE 2017-04-15 Conference Coverage This story was updated on 18 April 2017 to correct an error. Cerebrospinal fluid biomarkers of Alzheimer’s disease have transformed clinical research, but transferring this technology to the clinic has not been easy. Even after intense ...

Next-Generation Tau PET Tracers Strut Their Stuff

CONFERENCE COVERAGE 2017-04-14 Conference Coverage The current crop of tau PET tracers have yielded new insights into the progression of Alzheimer’s disease, but they are plagued by problems. At the 13th International Conference on Alzheimer’s and Parkinson’s Diseases, held March 29 to ...

After Solanezumab: Where Should Alzheimer’s Research Go?

CONFERENCE COVERAGE 2017-01-31 Conference Coverage At a postmortem discussion for solanezumab therapy in mild Alzheimer’s disease, held January 19 in London, members of the top echelons of AD research in the UK and other countries discussed CSF biomarker data from the Expedition 3 ...

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