331007 RESULTS
RESEARCH NEWS 2012-07-16 Research News Of four potential passive immunotherapies, scientists heading the Alzheimer's Prevention Initiative chose the relative newcomer crenezumab for an upcoming secondary prevention trial in asymptomatic people carrying familial Alzheimer’s d
United States
COMMENT There remain many families with ALS where the causative genes are yet to be discovered. In our Department of Neurology at the University of Tokyo, causative genes are unidentified in approximately half of ALS families. In PFN1-associated familial ALS (FAL
COMMENT John Landers and colleagues have successfully used exome capture followed by deep sequencing to identify novel mutations in the profilin gene (PFN1) that cause familial amyotrophic lateral sclerosis (FALS). The application of this methodology has greatly
COMMENT Controversy makes for better news than consensus but we need to keep in mind that there is considerable agreement about the links between PS1 and autophagy defects in AD. Four different lab groups agree that autophagy is disrupted by PS-deletion and/or PS
Israel
RESEARCH NEWS 2012-07-15 Research News Another handful of familial amyotrophic lateral sclerosis cases are explained, with a July 15 report in Nature, as being caused by mutations in profilin. Profilin catalyzes the formation of actin filaments. The new mutations, which inhibit a
PAPER Miller JW, Smith BN, Topp SD, Al-Chalabi A, Shaw CE, Vance C
PAPER Cheyuo C, Yang WL, Wang P
PAPER Kumar A, Sharma N, Gupta A, Kalonia H, Mishra J
PAPER Tiwari V, Chopra K
PAPER Iwano T, Masuda A, Kiyonari H, Enomoto H, Matsuzaki F
PAPER Vaccaro A, Tauffenberger A, Ash PE, Carlomagno Y, Petrucelli L, Parker JA
PAPER Qi WW, Zhong LY, Li XR, Li G, Liu ZX, Hu JF, Chen NH
PAPER Yamaguchi Y, Saito K, Matsuno T, Takeda K, Hino M
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