PAPER Braidy N, Jayasena T, Poljak A, Sachdev PS
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PAPER Dries DR, Yu G, Herz J
Extracting β-amyloid from Alzheimer's disease.
Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3199-200. PubMed: 22328154PAPER Corbett A, Smith J, Creese B, Ballard C
Treatment of behavioral and psychological symptoms of Alzheimer's disease.
Curr Treat Options Neurol. 2012 Apr;14(2):113-25. PubMed: 22328204PAPER Adams MK, Simpson JA, Richardson AJ, English DR, Aung KZ, Makeyeva GA, Guymer RH, Giles GG, Hopper J, Robman LD, Baird PN
Apolipoprotein E gene associations in age-related macular degeneration: the Melbourne Collaborative Cohort Study.
Am J Epidemiol. 2012 Mar 15;175(6):511-8. PubMed: 22328704PAPER Song M, Xiong JX, Wang YY, Tang J, Zhang B, Bai Y
VIP enhances phagocytosis of fibrillar beta-amyloid by microglia and attenuates amyloid deposition in the brain of APP/PS1 mice.
PLoS One. 2012;7(2):e29790. PubMed: 22328918PAPER Mattsson N, Rajendran L, Zetterberg H, Gustavsson M, Andreasson U, Olsson M, Brinkmalm G, Lundkvist J, Jacobson LH, Perrot L, Neumann U, Borghys H, Mercken M, Dhuyvetter D, Jeppsson F, Blennow K, Portelius E
BACE1 inhibition induces a specific cerebrospinal fluid β-amyloid pattern that identifies drug effects in the central nervous system.
PLoS One. 2012;7(2):e31084. PubMed: 22328928PAPER Rossello XS, Igbavboa U, Weisman GA, Sun GY, Wood WG
AP-2β regulates amyloid beta-protein stimulation of apolipoprotein E transcription in astrocytes.
Brain Res. 2012 Mar 20;1444:87-95. PubMed: 22325097PAPER Kou J, Song M, Pattanayak A, Lim JE, Yang J, Cao D, Li L, Fukuchi K
Combined treatment of Aβ immunization with statin in a mouse model of Alzheimer's disease.
J Neuroimmunol. 2012 Mar;244(1-2):70-83. PubMed: 22326143PAPER Zampagni M, Wright D, Cascella R, D'Adamio G, Casamenti F, Evangelisti E, Cardona F, Goti A, Nacmias B, Sorbi S, Liguri G, Cecchi C
Novel S-acyl glutathione derivatives prevent amyloid oxidative stress and cholinergic dysfunction in Alzheimer disease models.
Free Radic Biol Med. 2012 Apr 15;52(8):1362-71. PubMed: 22326489PAPER Hashimoto M, Aoki M, Winblad B, Tjernberg LO
A novel approach for Aβ₁₋₄₀ quantification using immuno-PCR.
J Neurosci Methods. 2012 Apr 15;205(2):364-7. PubMed: 22327103Suzanne Guenette on Novel GαS-protein signaling associated with membrane-tethered amyloid precursor protein intracellular domain.
COMMENT This is an excellent study. Not only is the novel interaction of APP/APLP C-terminal fragments with GαS shown to trigger neurite outgrowth, but also the involvement of cAMP/PKA activation and GSK-3β inhibition is in agreement with published evidence showi
Andres M. Lozano on Memory enhancement and deep-brain stimulation of the entorhinal area.
COMMENT The work from the group at UCLA is exciting and could have important implications for patients with memory disturbances. Just as deep-brain stimulation has been used to modify the activity of brain areas involved in movement in over 80,000 patients with P
Andres M. Lozano
Toronto Western HospitalToronto, Canada
Adam Kline on Upping Brain ApoE, Drug Treats Alzheimer's Mice
COMMENT Some LXR ligands interact directly with γ-secretase. The structure of bexarotene suggests that it, too, may have a direct interaction with the complex. Given the rapidity of the effects observed, it would be interesting to see data for this compound in a
Gunnar Gouras on Intracellular Aβ Causes Neurodegeneration in Mice
COMMENT As highlighted in the news story, Abramowski and colleagues chose a risky approach in generating mice directly expressing Aβ40 or 42, thereby likely precluding the normal trafficking and localization of Aβ. While we have shied away from studying Aβ biolog
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