PAPER Joutsa J, Kaasinen V
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PAPER Wagner SL, Zhang C, Cheng S, Nguyen P, Zhang X, Rynearson KD, Wang R, Li Y, Sisodia SS, Mobley WC, Tanzi RE
Soluble γ-secretase modulators selectively inhibit the production of the 42-amino acid amyloid β peptide variant and augment the production of multiple carboxy-truncated amyloid β species.
Biochemistry. 2014 Feb 4;53(4):702-13. Epub 2014 Jan 22 PubMed: 24401146PAPER Teng E, Yamasaki TR, Tran M, Hsiao JJ, Sultzer DL, Mendez MF
Cerebrospinal fluid biomarkers in clinical subtypes of early-onset Alzheimer's disease.
Dement Geriatr Cogn Disord. 2014;37(5-6):307-14. Epub 2013 Dec 31 PubMed: 24401901PAPER Stygelbout V, Leroy K, Pouillon V, Ando K, D'Amico E, Jia Y, Luo HR, Duyckaerts C, Erneux C, Schurmans S, Brion JP
Inositol trisphosphate 3-kinase B is increased in human Alzheimer brain and exacerbates mouse Alzheimer pathology.
Brain. 2014 Feb;137(Pt 2):537-52. Epub 2014 Jan 8 PubMed: 24401760PAPER Kovac A, Somikova Z, Zilka N, Novak M
Liquid chromatography-tandem mass spectrometry method for determination of panel of neurotransmitters in cerebrospinal fluid from the rat model for tauopathy.
Talanta. 2014 Feb 15;119:284-90. Epub 2013 Oct 22 PubMed: 24401416Lee Honigberg
GenentechUnited States
Lower Motor Neuron Pathology Links ALS and FTLD
RESEARCH NEWS 2014-01-09 Research News Researchers continue to be puzzled by the dual manifestation of TDP-43 proteinopathies as amyotrophic lateral sclerosis, frontotemporal lobar degeneration, or even both. The latest study may help them by confirming that many people with FTLD
PAPER Martinez-Lage M, Molina-Porcel L, Falcone D, McCluskey L, Lee VM, Van Deerlin VM, Trojanowski JQ
TDP-43 pathology in a case of hereditary spastic paraplegia with a NIPA1/SPG6 mutation.
Acta Neuropathol. 2012 Aug;124(2):285-91. PubMed: 22302102PAPER Kamada M, Izumi Y, Ayaki T, Nakamura M, Kagawa S, Kudo E, Sako W, Maruyama H, Nishida Y, Kawakami H, Ito H, Kaji R
Clinicopathologic features of autosomal recessive amyotrophic lateral sclerosis associated with optineurin mutation.
Neuropathology. 2014 Feb;34(1):64-70. Epub 2013 Jul 29 PubMed: 23889540PAPER Mackenzie IR, Neumann M, Baborie A, Sampathu DM, Du Plessis D, Jaros E, Perry RH, Trojanowski JQ, Mann DM, Lee VM
A harmonized classification system for FTLD-TDP pathology.
Acta Neuropathol. 2011 Jul;122(1):111-3. Epub 2011 Jun 5 PubMed: 21644037PAPER Katada R, Akdemir G, Asavapanumas N, Ratelade J, Zhang H, Verkman AS
Greatly improved survival and neuroprotection in aquaporin-4-knockout mice following global cerebral ischemia.
FASEB J. 2014 Feb;28(2):705-14. Epub 2013 Nov 1 PubMed: 24186965PAPER Vaucher E, Hamel E
Cholinergic basal forebrain neurons project to cortical microvessels in the rat: electron microscopic study with anterogradely transported Phaseolus vulgaris leucoagglutinin and choline acetyltransferase immunocytochemistry.
J Neurosci. 1995 Nov;15(11):7427-41. PubMed: 7472495Didier Lochmatter
NeuroscienceBonn, Germany
Jason Goodman
PHILADELPHIA, United States
Carl Horn
Jace Biomedical, Inc.Madison, United States
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