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Emily Reedich, C.J. Heckman, Katharina Quinlan on Motor Cortex Layer V Pyramidal Neurons Exhibit Dendritic Regression, Spine Loss, and Increased Synaptic Excitation in the Presymptomatic hSOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis.

COMMENT Cortical abnormalities in hSOD1 G93A mouse model confirm a key role of synaptic dysfunction in ALS Amyotrophic lateral sclerosis (ALS) is characterized by the concomitant dysfunction of corticospinal motoneurons (CSMNs) in the primary motor cortex, and ...

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