RESEARCH NEWS 2017-08-15 Research News Talk about instant gratification. According to an August 8 paper in Cell Reports, injecting a fragment of the protein klotho markedly improves memory and motor function in mice. Klotho is a protein associated with cognitive function in ...
RESEARCH NEWS 2017-08-15 Research News Genetic forces drive a sizable portion of Alzheimer’s disease, yet only a fraction of cases thus far are explained by known mutations. A handful of recent papers used genomic sequencing to fish out new variants that, while exceedingly rare, ...
PAPER Gitlin LN, Kales HJ, Marx K, Stanislawski B, Lyketsos C
A randomized trial of a web-based platform to help families manage dementia-related behavioral symptoms: The WeCareAdvisor™.Contemp Clin Trials. 2017 Aug 8; PubMed: 28800895
PAPER Datta A, Chai YL, Tan JM, Lee JH, Francis PT, Chen CP, Sze SK, Lai MK
An iTRAQ-based proteomic analysis reveals dysregulation of neocortical synaptopodin in Lewy body dementias.Mol Brain. 2017 Aug 11;10(1):36. PubMed: 28800743
PAPER Bella ED, Tramacere I, Antonini G, Borghero G, Capasso M, Caponnetto C, Chiò A, Corbo M, Eleopra R, Filosto M, Giannini F, Granieri E, Bella V, Lunetta C, Mandrioli J, Mazzini L, Messina S, Monsurrò MR, Mora G, Riva N, Rizzi R, Siciliano G, Silani V, Simone I, Sorarù G, Volanti P, Lauria G
Protein misfolding, amyotrophic lateral sclerosis and guanabenz: protocol for a phase II RCT with futility design (ProMISe trial).BMJ Open. 2017 Aug 11;7(8):e015434. PubMed: 28801400
PAPER Ulland TK, Song WM, Huang SC, Ulrich JD, Sergushichev A, Beatty WL, Loboda AA, Zhou Y, Cairns NJ, Kambal A, Loginicheva E, Gilfillan S, Cella M, Virgin HW, Unanue ER, Wang Y, Artyomov MN, Holtzman DM, Colonna M28802038
PAPER Stephan BC, Harrison SL, Keage HA, Babateen A, Robinson L, Siervo M28801790
PAPER Álvarez-Arellano L, Pedraza-Escalona M, Blanco-Ayala T, Camacho-Concha N, Cortés-Mendoza J, Pérez-Martínez L, Pedraza-Alva G
Autophagy impairment by caspase-1-dependent inflammation mediates memory loss in response to β-Amyloid peptide accumulation.J Neurosci Res. 2017 Aug 12; PubMed: 28801921
CONFERENCE COVERAGE 2017-08-12 Conference Coverage Part 2 of a two-part story. Click here for Part 1. The two hallmark pathologies of Alzheimer’s disease, amyloid plaques and tau tangles, play different roles in disease progression. Accumulating research suggests that amyloid plaques ...
CONFERENCE COVERAGE 2017-08-12 Conference Coverage Part 1 of a two-part story. Click here for Part 2. While biomarkers have opened a window onto Alzheimer’s pathogenesis, the view has remained cloudy. At the Alzheimer’s Association International Conference 2017 held July 16-20 in ...
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Mayo ClinicJacksonville, United States
COMMENT The results from FINGER show that its multidomain intervention, including cognitive training, leads to a small improvement of cognitive functioning in both the intervention and control condition over a 24-month period. The intervention group improved more ...
CONFERENCE COVERAGE 2017-08-11 Conference Coverage Spurred by the 2013 G8 Dementia Summit in London and by the First WHO Ministerial Conference on Global Action Against Dementia in March 2015, The Lancet commissioned an expert project to review available evidence and recommend how best ...
PAPER Prince M28735856
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