Research Brief: Auguste D.'s Mutation Identified?

RESEARCH NEWS 2010-05-20 Research News Writing the latest pages of an anthropological mystery, scientists propose in this month’s Archives of Neurology that it is highly possible that Auguste Deter, the first identified Alzheimer disease patient, carried the N141I presenilin-2 mu

PAPER Chang LK, Zhao JH, Liu HL, Wu JW, Chuang CK, Liu KT, Chen JT, Tsai WB, Ho Y

The importance of steric zipper on the aggregation of the MVGGVV peptide derived from the amyloid beta peptide.

J Biomol Struct Dyn. 2010 Aug;28(1):39-50. PubMed: 20476794

PAPER

Biomarkers may help predict risk of Alzheimer's disease.

J Inherit Metab Dis. 2010 Jun 8; PubMed: 20477523

PAPER Ereshefsky L, Jhee S, Yen M, Moran S, Pretorius S, Adams J

Cerebrospinal fluid beta-amyloid and dynabridging in Alzheimer's disease drug development.

Biomark Med. 2009 Dec;3(6):711-21. PubMed: 20477709

PAPER Mattsson N, Zetterberg H

Alzheimer's disease and CSF biomarkers: key challenges for broad clinical applications.

Biomark Med. 2009 Dec;3(6):735-7. PubMed: 20477711

PAPER Juréus A, Swahn BM, Sandell J, Jeppsson F, Johnson AE, Johnström P, Neelissen JA, Sunnemark D, Farde L, Svensson SP

Characterization of AZD4694, a novel fluorinated Abeta plaque neuroimaging PET radioligand.

J Neurochem. 2010 Aug;114(3):784-94. PubMed: 20477945

PAPER Hughes M, Snetkov V, Rose RS, Trousil S, Mermoud JE, Dingwall C

Neurite-like structures induced by mevalonate pathway blockade are due to the stability of cell adhesion foci and are enhanced by the presence of APP.

J Neurochem. 2010 Aug;114(3):832-42. PubMed: 20477946

PAPER Yu C, Nwabuisi-Heath E, Laxton K, LaDu MJ

Endocytic pathways mediating oligomeric Abeta42 neurotoxicity.

Mol Neurodegener. 2010;5:19. PubMed: 20478062

PAPER Fang CL, Wu WH, Liu Q, Sun X, Ma Y, Zhao YF, Li YM

Dual functions of beta-amyloid oligomer and fibril in Cu(II)-induced H2O2 production.

Regul Pept. 2010 Aug 9;163(1-3):1-6. PubMed: 20478342

PAPER Seppälä TT, Herukka SK, Hänninen T, Tervo S, Hallikainen M, Soininen H, Pirttilä T

Plasma Abeta42 and Abeta40 as markers of cognitive change in follow-up: a prospective, longitudinal, population-based cohort study.

J Neurol Neurosurg Psychiatry. 2010 Oct;81(10):1123-7. PubMed: 20478847

PAPER Sureshbabu N, Kirubagaran R, Thangarajah H, Malar EJ, Jayakumar R

Lipid-induced conformational transition of amyloid beta peptide fragments.

J Mol Neurosci. 2010 Jul;41(3):368-82. PubMed: 20480256

PAPER Novelli MM, Nitrini R, Caramelli P

Validation of the Brazilian version of the quality of life scale for patients with Alzheimer's disease and their caregivers (QOL-AD).

Aging Ment Health. 2010 Jul;14(5):624-31. PubMed: 20480421

PAPER Saraiva AM, Cardoso I, Saraiva MJ, Tauer K, Pereira MC, Coelho MA, Möhwald H, Brezesinski G

Randomization of amyloid-β-peptide(1-42) conformation by sulfonated and sulfated nanoparticles reduces aggregation and cytotoxicity.

Macromol Biosci. 2010 Oct 8;10(10):1152-63. PubMed: 20480510

PAPER Wolk DA, Dickerson BC,

Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease.

Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10256-61. PubMed: 20479234

PAPER Grune T, Botzen D, Engels M, Voss P, Kaiser B, Jung T, Grimm S, Ermak G, Davies KJ

Tau protein degradation is catalyzed by the ATP/ubiquitin-independent 20S proteasome under normal cell conditions.

Arch Biochem Biophys. 2010 Aug 15;500(2):181-8. PubMed: 20478262