PAPER Rosen H, Sanna G, Alfonso C

Egress: a receptor-regulated step in lymphocyte trafficking.

Immunol Rev. 2003 Oct;195:160-77. PubMed: 12969317

PAPER Baumruker T, Billich A, Brinkmann V

FTY720, an immunomodulatory sphingolipid mimetic: translation of a novel mechanism into clinical benefit in multiple sclerosis.

Expert Opin Investig Drugs. 2007 Mar;16(3):283-9. PubMed: 17302523

PAPER Kappos L, Radue EW, O'Connor P, Polman C, Hohlfeld R, Calabresi P, Selmaj K, Agoropoulou C, Leyk M, Zhang-Auberson L, Burtin P,

A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis.

N Engl J Med. 2010 Feb 4;362(5):387-401. PubMed: 20089952

PAPER Fenno L, Yizhar O, Deisseroth K

The development and application of optogenetics.

Annu Rev Neurosci. 2011;34:389-412. PubMed: 21692661

Gladstone Workshop: ApoE4

CONFERENCE COVERAGE SERIES San Francisco: Tweaking Brain ApoE Reduces Aβ, Symptoms San Francisco: GABA Neurons Blamed for Memory Loss in ApoE Mice Considering the dramatic impact of its E4 allelic variant on Alzheimer’s disease risk, apolipoprotein E arguably has drawn scant attent

PAPER Morgan CP, Bale TL

Early prenatal stress epigenetically programs dysmasculinization in second-generation offspring via the paternal lineage.

J Neurosci. 2011 Aug 17;31(33):11748-55. PubMed: 21849535

PAPER Shohet JM, Ghosh R, Coarfa C, Ludwig A, Benham AL, Chen Z, Patterson DM, Barbieri E, Mestdagh P, Sikorski DN, Milosavljevic A, Kim ES, Gunaratne PH

A genome-wide search for promoters that respond to increased MYCN reveals both new oncogenic and tumor suppressor microRNAs associated with aggressive neuroblastoma.

Cancer Res. 2011 Jun 1;71(11):3841-51. PubMed: 21498633

PAPER Kent OA, Chivukula RR, Mullendore M, Wentzel EA, Feldmann G, Lee KH, Liu S, Leach SD, Maitra A, Mendell JT

Repression of the miR-143/145 cluster by oncogenic Ras initiates a tumor-promoting feed-forward pathway.

Genes Dev. 2010 Dec 15;24(24):2754-9. PubMed: 21159816

PAPER Cordes KR, Sheehy NT, White MP, Berry EC, Morton SU, Muth AN, Lee TH, Miano JM, Ivey KN, Srivastava D

miR-145 and miR-143 regulate smooth muscle cell fate and plasticity.

Nature. 2009 Aug 6;460(7256):705-10. PubMed: 19578358

Tonya Pilkey

United States

soni Kumar

India

Yaarit Nachum-Biala

Israel

Slicing and Dicing: TDP-43 Teams Up With Nucleases to Make MicroRNAs

RESEARCH NEWS 2012-02-16 Research News TDP-43 shepherds select microRNAs through their maturation process from nuclear transcripts to grown-up regulatory fragments set loose in the cytoplasm, according to a paper in the February 9 Proceedings of the National Academy of Sciences o

San Francisco: GABA Neurons Blamed for Memory Loss in ApoE Mice

CONFERENCE COVERAGE 2012-02-16 Conference Coverage People carrying one copy of the apolipoprotein E4 gene variant are up to four times more likely to develop Alzheimer’s disease, and that risk rises up to 15-fold in E4 homozygotes—but what makes the protein so harmful? Research suggest

San Francisco: Tweaking Brain ApoE Reduces Aβ, Symptoms

CONFERENCE COVERAGE 2012-02-16 Conference Coverage Considering the dramatic impact of its E4 allelic variant on Alzheimer’s disease risk, apolipoprotein E arguably has drawn scant attention from AD drug developers, but recent research may help turn the tide. At a workshop organized by