PAPER Uriri-Glover J, McCarthy M, Cesarotti E

Solving the puzzle of Alzheimer disease.

Nurse Pract. 2012 Sep 10;37(9):20-7; quiz 27-8. PubMed: 22850534

PAPER Wanngren J, Ottervald J, Parpal S, Portelius E, Strömberg K, Borgegård T, Klintenberg R, Juréus A, Blomqvist J, Blennow K, Zetterberg H, Lundkvist J, Rosqvist S, Karlström H

Second Generation γ-Secretase Modulators Exhibit Different Modulation of Notch β and Aβ Production.

J Biol Chem. 2012 Sep 21;287(39):32640-50. PubMed: 22851182

Henrik Zetterberg on Aβ’s Good Side—Can It Improve Symptoms of Multiple Sclerosis?

COMMENT These results are highly unexpected and in need of replication, but they are also very interesting in the light of what we currently know about Aβ homeostasis in several diseases of severe neuroinflammation, for example, bacterial meningitis, HIV-associat

PAPER Ousman SS, Tomooka BH, van Noort JM, Wawrousek EF, O'Connor KC, Hafler DA, Sobel RA, Robinson WH, Steinman L

Protective and therapeutic role for alphaB-crystallin in autoimmune demyelination.

Nature. 2007 Jul 26;448(7152):474-9. PubMed: 17568699

Jürgen Götz on Interaction of Endogenous Tau Protein with Synaptic Proteins Is Regulated by N-Methyl-D-aspartate Receptor-dependent Tau Phosphorylation.

COMMENT Mondragon-Rodriguez and colleagues confirm a role for tau in the dendrite under physiological conditions and address the role that distinct phospho-epitopes of tau have in mediating Aβ toxicity, in responding to NMDA, and in interaction of tau with PSD95.

Lauren Chazal

Insearch Group
Saint Petersburg, United States

Global Consortium for the Standardization of CSF Biomarkers

CONFERENCE COVERAGE SERIES CSF Markers: Goodbye, Research Use Only; Hello, Clinical Metrology, Certification Heavies Take CSF Tests Under Their Wings The Global Consortium for the Standardization of CSF Biomarkers met in Vancouver, Canada, on 14 July 2012 to assess moves on two fro

Eva Schier

Lausanne, Switzerland

Metrology, Certification Heavies Take CSF Tests Under Their Wings

CONFERENCE COVERAGE 2012-08-02 Conference Coverage  For cerebrospinal fluid tests of Alzheimer’s biomarkers, the time has come to grow up. The markers have shown great promise while being studied with research use only (RUO) assays, but as large multicenter studies and drug trials are

Aβ’s Good Side—Can It Improve Symptoms of Multiple Sclerosis?

RESEARCH NEWS 2012-08-02 Research News Aβ, a sticky peptide associated with neurotoxicity and inflammation in Alzheimer’s disease, normally plays the villain. Now, in the August 1 Science Translational Medicine, researchers led by Lawrence Steinman at Stanford University, Palo Al

PAPER Sibley CR, Seow Y, Curtis H, Weinberg MS, Wood MJ

Silencing of Parkinson's disease-associated genes with artificial mirtron mimics of miR-1224.

Nucleic Acids Res. 2012 Oct 1;40(19):9863-75. PubMed: 22848108

PAPER McFarland KN, Das S, Sun TT, Leyfer D, Xia E, Sangrey GR, Kuhn A, Luthi-Carter R, Clark TW, Sadri-Vakili G, Cha JH

Genome-wide histone acetylation is altered in a transgenic mouse model of Huntington's disease.

PLoS One. 2012;7(7):e41423. PubMed: 22848491

PAPER Vaccaro A, Patten SA, Ciura S, Maios C, Therrien M, Drapeau P, Kabashi E, Parker JA

Methylene blue protects against TDP-43 and FUS neuronal toxicity in C. elegans and D. rerio.

PLoS One. 2012;7(7):e42117. PubMed: 22848727

PAPER Schulz KL, Eckert A, Rhein V, Mai S, Haase W, Reichert AS, Jendrach M, Müller WE, Leuner K

A new link to mitochondrial impairment in tauopathies.

Mol Neurobiol. 2012 Aug;46(1):205-16. PubMed: 22847631

PAPER Meiner Z, Rosenmann H

[Biological markers in the diagnosis of dementia and Alzheimer's disease].

Harefuah. 2012 May;151(5):289-93, 318. PubMed: 22844733