RESEARCH NEWS 2013-07-03 Research News What determines if APP will be processed to Aβ? Researchers led by Dora Kovacs, Massachusetts General Hospital, Charlestown, present a potential explanation in the July 3 Journal of Neuroscience. They report, for the first time, that APP bin
RESEARCH NEWS 2013-07-03 Research News Release of inflammatory cytokines implicated in Alzheimer’s disease requires signaling through inflammasomes. What regulates these innate immune complexes? A June 30 Nature Immunology paper highlights the essential role of CD36, an Aβ-bindin
RESEARCH NEWS 2013-07-03 Research News Scientists have discovered yet another function for β-secretase (BACE1), the enzyme that kick-starts amyloidogenic processing of the amyloid-β precursor protein. In the June 21 EMBO Journal, researchers led by Carmen Birchmeier, Max Delbrück
Victoria University of WellingtonWellington, New Zealand
RESEARCH MODELS Neuropathology Increased total tau and phosphorylated tau species (Thr181, Ser199, Thr231) in the amygdala and hippocampus starting at three months. Cognition/Behavior Spatial memory deficits starting at five months by the Morris water maze. Olfactory def
RESEARCH MODELS Summary These transgenic mice express mutant human APP with both the Swedish (K670N/M671L) and London (V717I) mutations. They develop age-associated amyloid plaques and cognitive impairment. Neuropathology These mice exhibit age-dependent increases in Aβ4