PAPER Sheedy FJ, Grebe A, Rayner KJ, Kalantari P, Ramkhelawon B, Carpenter SB, Becker CE, Ediriweera HN, Mullick AE, Golenbock DT, Stuart LM, Latz E, Fitzgerald KA, Moore KJ
SEARCH RESULTS
331009 RESULTS
Steve Elrod
Upsher-Smith LaboratoriesMaple Grove, United States
Robert Vann
LillyCharlotte, United States
Tobias Hartmann on Peer Pressure? "Pal" Leads APP Down Amyloid Path
COMMENT For many years, evidence accumulated that AD has extensive links to lipid metabolism. Dora Kovacs' group was one of the first to identify such a link on the molecular level with their ACAT targeted experiments. There is also extensive evidence sugges
Robert Vassar on Peer Pressure? "Pal" Leads APP Down Amyloid Path
COMMENT The paper by Kovacs and colleagues reports the discovery that a significant proportion of APP in the cell is palmitoylated and enriched in lipid rafts. APP palmitoylation increased the colocalization of APP with BACE1, the β-secretase. Consequently, BACE1
Frank Heppner on CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation.
COMMENT The identification of CD36 as a key upstream regulator of NLRP3 activation by endogenous, potentially dangerous ligands in three major diseases—namely atherosclerosis, Alzheimer’s disease (AD), and type 2 diabetes—is an important and encouraging finding f
Luigi Puglielli on Peer Pressure? "Pal" Leads APP Down Amyloid Path
COMMENT This paper presents data indicating that palmitoylation of APP in the early secretory pathway regulates its processing by BACE1. The findings are novel and offer a previously unknown aspect of APP biology that could be targeted for therapeutic purposes. T
Stefan Lichtenthaler on Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles.
COMMENT This is a scientifically exciting story that is genetically well controlled, including the conditional knockout of the substrate neuregulin 1. The paper adds muscle spindle formation to the growing list of BACE1 in-vivo functions. Another important aspect
Weihong Song on Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles.
COMMENT Previously, Christian Haass’s group (Willem et al., 2006) and Riqiang Yan’s team (Hu et al., 2006) demonstrated that BACE1 regulates myelination by processing type III NRG1, and that disruption of the BACE1 gene resulted in hypomyelination in the central
Katherine LaClair on Bexarotene Revisited: Improves Mouse Memory But No Effect on Plaques
COMMENT Like many others, our group was excited about the findings published by Gary Landreth's group (see Cramer et al., 2013) and we repeated the main experiments with short-term dosing of bexarotene in the mutant APPSWE/PS1ΔE9 mouse model. While the ABCA1
European Courts Strike Down JAI Immunotherapy Patent
COMMUNITY NEWS 2013-07-03 Community News One company cannot own all passive immunotherapies for Alzheimer’s disease, courts in Europe and the UK ruled June 24 and 25, respectively. Specifically, the decisions overturned a 1997 patent, 1,994,937, held by Janssen Alzheimer Immunothe
Peer Pressure? "Pal" Leads APP Down Amyloid Path
RESEARCH NEWS 2013-07-03 Research News What determines if APP will be processed to Aβ? Researchers led by Dora Kovacs, Massachusetts General Hospital, Charlestown, present a potential explanation in the July 3 Journal of Neuroscience. They report, for the first time, that APP bin
Scavenger Receptor Regulates Inflammasome Activation, IL-1β
RESEARCH NEWS 2013-07-03 Research News Release of inflammatory cytokines implicated in Alzheimer’s disease requires signaling through inflammasomes. What regulates these innate immune complexes? A June 30 Nature Immunology paper highlights the essential role of CD36, an Aβ-bindin
Paper Alert: BACE1 Required for Muscle Spindle, Motor Control
RESEARCH NEWS 2013-07-03 Research News Scientists have discovered yet another function for β-secretase (BACE1), the enzyme that kick-starts amyloidogenic processing of the amyloid-β precursor protein. In the June 21 EMBO Journal, researchers led by Carmen Birchmeier, Max Delbrück
Rosemary Heathcott
Victoria University of WellingtonWellington, New Zealand
Current Filters
No filters selected