Hsp60 (24/HSP60)

ANTIBODY monoclonal 24/HSP60 manufacturer Cat# 611562 <br />Reference: <br /><a href="/papers/mitochondrial-g-secretase-participates-metabolism-mitochondria-associated-amyloid-precursor" target="_new">Pavlov PF, 2010</a>

Torleif Hard on Ion mobility-mass spectrometry reveals a conformational conversion from random assembly to β-sheet in amyloid fibril formation.

COMMENT The toxic aggregates of the Aβ peptide that are thought to be responsible for at least the initial AD pathogenesis are either small soluble oligomers or larger, but still soluble, protofibrils that contain smaller aggregates as building blocks. A major pr

Brigita Urbanc on Ion mobility-mass spectrometry reveals a conformational conversion from random assembly to β-sheet in amyloid fibril formation.

COMMENT Protein Assembly Pathways Revealed? The question of assembly pathways is central to understanding the formation of protein structures associated with amyloid diseases. The latest research by Bleiholder et al. from the lab of Mike Bowers, recently publishe

David Teplow on Ion mobility-mass spectrometry reveals a conformational conversion from random assembly to β-sheet in amyloid fibril formation.

COMMENT Filling a Vacuum in Knowledge...With a Vacuum! Ion-Mobility Mass Spectrometry Provides Insight Into Amyloid Protein Assembly In an exciting new paper published in Nature Chemistry, Bleiholder et al. report that the technique of ion mobility-mass spectrome

Mitofilin

ANTIBODY polyclonal manufacturer Cat# AB8164<br />Reference:<br /><a href="/papers/mitochondrial-g-secretase-participates-metabolism-mitochondria-associated-amyloid-precursor" target="_new">Pavlov PF, 2010</a> liquid, ra

Opa1 (V-20)

ANTIBODY polyclonal manufacturer Cat# sc-30572<br />Reference: <br /><a href="/papers/mitochondrial-g-secretase-participates-metabolism-mitochondria-associated-amyloid-precursor" target="_new">Pavlov PF, 2010</a> immunog

BAF170 (E-6)

ANTIBODY monoclonal E-6 manufacturer Cat# sc-17838 immunogen = amino acids 1093-1208 near the C-terminus of BAF170 of human origin liquid, PBS, azide, gelatin detects BAF170 IgG₁ Miscellaneous Santa Cruz Mouse Human Mouse BAF170 http://alzfo

Chris Carter on Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis.

COMMENT Is this effect related to antibodies to β amyloid generated by inoculation? Such effects may be relevant to the proposed use of β amyloid antibodies in Alzheimer's disease, and to their toxicity (Ferrer et al., 2004). Immunization with tau in mice al

Chris Carter on Alzheimer's disease plaques and tangles: cemeteries of a pyrrhic victory of the immune defence network against herpes simplex infection at the expense of complement and inflammation-mediated neuronal destruction.

COMMENT An online version of the full paper, with a NextBio highlighting service providing details of gene and scientific terms, is available at PolygenicPathways. 0 chris_car

Gordon Wilcock on Focus on the Locus! (Ceruleus, That Is, in Alzheimer’s Disease)

COMMENT That subcortical nuclei other than the basal nucleus, e.g., the locus, may play a part in AD has long been suspected. Some colleagues and I reported on a small study of cell counts in different subcortical nuclei in autopsy-confirmed AD and control subjec

PAPER Wilcock GK, Esiri MM, Bowen DM, Hughes AO

The differential involvement of subcortical nuclei in senile dementia of Alzheimer's type.

J Neurol Neurosurg Psychiatry. 1988 Jun;51(6):842-9. PubMed: 3404192

sakis papantsios

thessaloniki, Greece

Tom20 (FL-145)

ANTIBODY polyclonal manufacturer Cat# sc-11415<br />Reference: <br /><a href="/papers/mitochondrial-g-secretase-participates-metabolism-mitochondria-associated-amyloid-precursor" target="_new">Pavlov PF, 2010</a> immunog

COX-IV

ANTIBODY polyclonal manufacturer Cat# 4844<br />Reference: <br />(<a href="/papers/amyloid-v-peptide-oligomers-stimulate-ryr-mediated-ca2-release-inducing-mitochondrial" target="_new">Paula-Lima, 2010</a>, rabbit but uns

COX-IV (3E11)

ANTIBODY monoclonal 3E11 manufacturer Cat# 4850 immunogen = synthetic peptide corresponding to residues surrounding Lys29 of human COX IV liquid, protein-A purified, HEPES, NaCl, BSA, glycerol, azide.<br />Also available Biotinylated, cat# 6014<br />HR