Silent Vascular Disease May Hasten Dementia Progression

RESEARCH NEWS 2012-02-10 Research News Sometimes what you don’t know can hurt you. In a small pilot study of people with dementia, those who had occasional small clots of solid material flowing through their cerebral arteries declined nearly twice as fast on several cognitive mea

Virtual Reality Reveals Deep-Brain Memory Stimulus, Early AD Signs

RESEARCH NEWS 2012-02-10 Research News Deep-brain stimulation (DBS)—which delivers electrical pulses by wires directly to select brain areas—has been shown to calm Parkinson's tremors, and is being explored as a way to alleviate depression and relieve obsessive-compulsive be

PAPER Ravid R, Ferrer I

Brain banks as key part of biochemical and molecular studies on cerebral cortex involvement in Parkinson's disease.

FEBS J. 2012 Apr;279(7):1167-76. PubMed: 22313511

PAPER Fauvet B, Mbefo MK, Fares MB, Desobry C, Michael S, Ardah MT, Tsika E, Coune P, Prudent M, Lion N, Eliezer D, Moore DJ, Schneider B, Aebischer P, El-Agnaf OM, Masliah E, Lashuel HA

α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer.

J Biol Chem. 2012 May 4;287(19):15345-64. Epub 2012 Feb 7 PubMed: 22315227

PAPER Lundblad M, Decressac M, Mattsson B, Björklund A

Impaired neurotransmission caused by overexpression of α-synuclein in nigral dopamine neurons.

Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3213-9. PubMed: 22315428

PAPER Takuma K, Mizoguchi H, Funatsu Y, Hoshina Y, Himeno Y, Fukuzaki E, Kitahara Y, Arai S, Ibi D, Kamei H, Matsuda T, Koike K, Inoue M, Nagai T, Yamada K

Combination of chronic stress and ovariectomy causes conditioned fear memory deficits and hippocampal cholinergic neuronal loss in mice.

Neuroscience. 2012 Apr 5;207:261-73. PubMed: 22314316

PAPER Mosley RL, Hutter-Saunders JA, Stone DK, Gendelman HE

Inflammation and adaptive immunity in Parkinson's disease.

Cold Spring Harb Perspect Med. 2012 Jan;2(1):a009381. PubMed: 22315722

PAPER Ikenaka K, Katsuno M, Kawai K, Ishigaki S, Tanaka F, Sobue G

Disruption of axonal transport in motor neuron diseases.

Int J Mol Sci. 2012;13(1):1225-38. PubMed: 22312314

PAPER Wosiski-Kuhn M, Stranahan AM

Transient increases in dendritic spine density contribute to dentate gyrus long-term potentiation.

Synapse. 2012 Feb 8; PubMed: 22314918

PAPER Hegde ML, Mantha AK, Hazra TK, Bhakat KK, Mitra S, Szczesny B

Oxidative genome damage and its repair: Implications in aging and neurodegenerative diseases.

Mech Ageing Dev. 2012 Jan 31; PubMed: 22313689

PAPER Lee S, Kim W, Li Z, Hall GF

Accumulation of vesicle-associated human tau in distal dendrites drives degeneration and tau secretion in an in situ cellular tauopathy model.

Int J Alzheimers Dis. 2012;2012:172837. PubMed: 22315694

PAPER Fusco FR, Anzilotti S, Giampà C, Dato C, Laurenti D, Leuti A, Colucci D'Amato L, Perrone L, Bernardi G, Melone MA

Changes in the expression of extracellular regulated kinase (ERK 1/2) in the R6/2 mouse model of Huntington's disease after phosphodiesterase IV inhibition.

Neurobiol Dis. 2012 Apr;46(1):225-33. PubMed: 22311347

PAPER Rockenstein E, Ubhi K, Inglis C, Mante M, Patrick C, Adame A, Masliah E

Neuronal to oligodendroglial alpha-synuclein redistribution in a double transgenic model of multiple system atrophy.

Neuroreport. 2012 Mar 7;23(4):259-64. PubMed: 22314685

PAPER Lee EB, Lee VM, Trojanowski JQ

Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration.

Nat Rev Neurosci. 2012 Jan;13(1):38-50. PubMed: 22127299

PAPER Persengiev SP, Kondova II, Bontrop RE

The Impact of MicroRNAs on Brain Aging and Neurodegeneration.

Curr Gerontol Geriatr Res. 2012;2012:359369. PubMed: 22312330