PAPER La Joie R, Perrotin A, Barré L, Hommet C, Mézenge F, Ibazizene M, Camus V, Abbas A, Landeau B, Guilloteau D, De la Sayette V, Eustache F, Desgranges B, Chételat G

Region-specific hierarchy between atrophy, hypometabolism, and β-amyloid (Aβ) load in Alzheimer's disease dementia.

J Neurosci. 2012 Nov 14;32(46):16265-73. PubMed: 23152610

Kristel Sleegers on Enter the New Alzheimer’s Gene: TREM2 Variant Triples Risk

COMMENT These studies provide further evidence that the genetic architecture of Alzheimer's disease does indeed include rare variants of intermediate penetrance, analogous to our work on rare variants in the GRN (Brouwers et al., 2008) and CLU genes (Bettens

Sylvain Lesne on Accuracy of a panel of 5 cerebrospinal fluid biomarkers in the differential diagnosis of patients with dementia and/or parkinsonian disorders.

COMMENT This new report from Kaj Blennow and Oskar Hansson's group appears to support our own findings that soluble α-synuclein levels are increased in brains of subjects with AD (Larson et al., 2012). Whether this elevation corresponds to a "leakage of

David Sulzer on Development and characterization of a new Parkinson's disease model resulting from impaired autophagy.

COMMENT The line of mice introduced in this study indicates what happens when macroautophagy is specifically blocked in dopamine (DA) neurons by deletion of Atg7, a key component of the autophagy machinery. There have been, to my knowledge, three such floxed Atg7

Kristel Sleegers

University of Antwerp
Antwerpen, Belgium

PAPER Sulzer D, Mosharov E, Talloczy Z, Zucca FA, Simon JD, Zecca L

Neuronal pigmented autophagic vacuoles: lipofuscin, neuromelanin, and ceroid as macroautophagic responses during aging and disease.

J Neurochem. 2008 Jul;106(1):24-36. PubMed: 18384642

PAPER Lazarou M, Jin SM, Kane LA, Youle RJ

Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin.

Dev Cell. 2012 Feb 14;22(2):320-33. PubMed: 22280891

PAPER Ahmed I, Liang Y, Schools S, Dawson VL, Dawson TM, Savitt JM

Development and characterization of a new Parkinson's disease model resulting from impaired autophagy.

J Neurosci. 2012 Nov 14;32(46):16503-9. PubMed: 23152632

Gunjan Joshi

United States

Toxic Synuclein Corrupts Native in Wild-Type Mice

RESEARCH NEWS 2012-11-16 Research News The spread of toxic α-synuclein through the brain is not just for transgenic mice anymore. A new study from Virginia Lee and colleagues at the University of Pennsylvania School of Medicine, Philadelphia, suggests that toxic α-synuclein creep

PAPER Oyebode JR, Bradley P, Allen JL

Relatives' experiences of frontal-variant frontotemporal dementia.

Qual Health Res. 2013 Feb;23(2):156-66. PubMed: 23150527

PAPER van Der Veken P, Fülöp V, Rea D, Gerard M, Van Elzen R, Joossens J, Cheng JD, Baekelandt V, De Meester I, Lambeir AM, Augustyns K

P2-substituted N-acylprolylpyrrolidine inhibitors of prolyl oligopeptidase: biochemical evaluation, binding mode determination, and assessment in a cellular model of synucleinopathy.

J Med Chem. 2012 Nov 26;55(22):9856-67. PubMed: 23121075

PAPER Mollenhauer B, Trautmann E, Taylor P, Manninger P, Sixel-Döring F, Ebentheuer J, Trenkwalder C, Schlossmacher MG

Total CSF α-synuclein is lower in de novo Parkinson patients than in healthy subjects.

Neurosci Lett. 2013 Jan 4;532:44-8. PubMed: 23149132

PAPER Surguchov A

Synucleins: are they two-edged swords?

J Neurosci Res. 2013 Feb;91(2):161-6. PubMed: 23150342

PAPER Kim SS, Jang SA, Seo SR

CREB-mediated Bcl-2 expression contributes to RCAN1 protection from hydrogen peroxide-induced neuronal death.

J Cell Biochem. 2012 Nov 13; PubMed: 23150431