Claudia Späni

Switzerland

Michael G. Agadjanyan on Smuggling Antibodies to BACE Across the Blood-Brain Barrier

COMMENT Delivery of antibodies into the brain using bispecific antibodies is a very interesting strategy. I would be interested to hear more from the authors about the so-called full-length IgGs generated by cloning VL and VH regions into LPG3 and LPG4 vectors. H

PAPER Miyoshi N, Ishii H, Nagano H, Haraguchi N, Dewi DL, Kano Y, Nishikawa S, Tanemura M, Mimori K, Tanaka F, Saito T, Nishimura J, Takemasa I, Mizushima T, Ikeda M, Yamamoto H, Sekimoto M, Doki Y, Mori M

Reprogramming of mouse and human cells to pluripotency using mature microRNAs.

Cell Stem Cell. 2011 Jun 3;8(6):633-8. PubMed: 21620789

PAPER Pang ZP, Yang N, Vierbuchen T, Ostermeier A, Fuentes DR, Yang TQ, Citri A, Sebastiano V, Marro S, Südhof TC, Wernig M

Induction of human neuronal cells by defined transcription factors.

Nature. 2011 Aug 11;476(7359):220-3. PubMed: 21617644

Gregory Cole on RNA polymerase III drives alternative splicing of the potassium channel-interacting protein contributing to brain complexity and neurodegeneration.

COMMENT This paper by Massone and colleagues is intriguing in that they report that IL1-α elevates 38A RNA in a cyclo-oxygenase (COX) inhibitor-sensitive manner, and that AD brain has markedly elevated 38A RNA consistent with an inflammation-driven increase. They

Vinko Rajic

Australia

PAPER Il'ina TI

[Scientific and practical work of the students of medical schools].

Med Sestra. 1979 Feb;38(2):40-3. PubMed: 86144

Turning Human Fibroblasts Into Neurons; Making Safer Stem Cells

RESEARCH NEWS 2011-06-05 Research News Scientists are making slow but steady progress in stem cell technology. This week in Cell Stem Cell, researchers from Osaka University in Japan report a microRNA method to turn adult cells into induced pluripotent stem (iPS) cells without us

Can Non-Coding RNA Tie Inflammation to Alzheimer’s Disease?

RESEARCH NEWS 2011-06-05 Research News Some scientists believe that brain inflammation can trigger sporadic Alzheimer’s disease, but the precise pathways remain unclear. In the May 30 Journal of Cell Biology, researchers led by Aldo Pagano at the University of Genoa, Italy, prese

PAPER Swanepoel T, Harvey BH, Harden LM, Laburn HP, Mitchell D

Dissociation between learning and memory impairment and other sickness behaviours during simulated Mycoplasma infection in rats.

Brain Behav Immun. 2011 Nov;25(8):1607-16. PubMed: 21635947

PAPER Campesan S, Green EW, Breda C, Sathyasaikumar KV, Muchowski PJ, Schwarcz R, Kyriacou CP, Giorgini F

The kynurenine pathway modulates neurodegeneration in a Drosophila model of Huntington's disease.

Curr Biol. 2011 Jun 7;21(11):961-6. PubMed: 21636279

PAPER Langford-Smith A, Malinowska M, Langford-Smith KJ, Wegrzyn G, Jones S, Wynn R, Wraith JE, Wilkinson FL, Bigger BW

Hyperactive behaviour in the mouse model of mucopolysaccharidosis IIIB in the open field and home cage environments.

Genes Brain Behav. 2011 Aug;10(6):673-82. PubMed: 21635693

PAPER Mammadov B, Karakas N, Isik S

Comparison of long-term retinoic acid-based neural induction methods of bone marrow human mesenchymal stem cells.

In Vitro Cell Dev Biol Anim. 2011 Aug;47(7):484-91. PubMed: 21638161

PAPER Robillard JM, Federico CA, Tairyan K, Ivinson AJ, Illes J

Untapped ethical resources for neurodegeneration research.

BMC Med Ethics. 2011;12:9. PubMed: 21635769

PAPER Pan J, Han J, Borchers CH, Konermann L

Conformer-specific hydrogen exchange analysis of Aβ(1-42) oligomers by top-down electron capture dissociation mass spectrometry.

Anal Chem. 2011 Jul 1;83(13):5386-93. PubMed: 21635007