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The Aβ-induced NFAT apoptotic pathway is also activated by GSK-3 inhibition: implications for Alzheimer therapeutics.

J Neurosci. 2012 Jul 11;32(28):9454-6. PubMed: 22787030

PAPER Fuster-Matanzo A, Llorens-Martín M, Jurado-Arjona J, Avila J, Hernández F

Tau protein and adult hippocampal neurogenesis.

Front Neurosci. 2012;6:104. PubMed: 22787440

Benjamin Withey

Flagship Biosciences
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An effector-reduced anti-β-amyloid (Aβ) antibody with unique aβ binding properties promotes neuroprotection and glial engulfment of Aβ.

J Neurosci. 2012 Jul 11;32(28):9677-89. PubMed: 22787053

PAPER Duan W, Guo Y, Jiang H, Yu X, Li C

MG132 enhances neurite outgrowth in neurons overexpressing mutant TAR DNA-binding protein-43 via increase of HO-1.

Brain Res. 2011 Jun 23;1397:1-9. PubMed: 21620381

PAPER Takeuchi H, Kobayashi Y, Yoshihara T, Niwa J, Doyu M, Ohtsuka K, Sobue G

Hsp70 and Hsp40 improve neurite outgrowth and suppress intracytoplasmic aggregate formation in cultured neuronal cells expressing mutant SOD1.

Brain Res. 2002 Sep 13;949(1-2):11-22. PubMed: 12213295

J. de Belleroche

Neurogenetics Group, Centre for Neuroscience
London

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Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity.

Nature. 2012 May 24;485(7399):517-21. PubMed: 22622581

Shoji Tsuji

University of Tokyo, Graduate School of Medicine
Tokyo, United States

PAPER Bateman RJ, Xiong C, Benzinger TL, Fagan AM, Goate A, Fox NC, Marcus DS, Cairns NJ, Xie X, Blazey TM, Holtzman DM, Santacruz A, Buckles V, Oliver A, Moulder K, Aisen PS, Ghetti B, Klunk WE, McDade E, Martins RN, Masters CL, Mayeux R, Ringman JM, Rossor MN, Schofield PR, Sperling RA, Salloway S, Morris JC

Clinical and biomarker changes in dominantly inherited Alzheimer's disease.

N Engl J Med. 2012 Aug 30;367(9):795-804. PubMed: 22784036

PAPER Griffiths I, Klugmann M, Anderson T, Yool D, Thomson C, Schwab MH, Schneider A, Zimmermann F, McCulloch M, Nadon N, Nave KA

Axonal swellings and degeneration in mice lacking the major proteolipid of myelin.

Science. 1998 Jun 5;280(5369):1610-3. PubMed: 9616125

Eric M. Reiman on Protective APP Mutation Found—Supports Amyloid Hypothesis

COMMENT This elegant and important study finds an association between a rare APP variant and a lower risk of AD, and it provides strong evidence to suggest that the protective effects of this variant may be attributable to reductions in BACE1-mediated APP cleavag

PAPER Corrado L, Battistini S, Penco S, Bergamaschi L, Testa L, Ricci C, Giannini F, Greco G, Patrosso MC, Pileggi S, Causarano R, Mazzini L, Momigliano-Richiardi P, D'Alfonso S

Variations in the coding and regulatory sequences of the angiogenin (ANG) gene are not associated to ALS (amyotrophic lateral sclerosis) in the Italian population.

J Neurol Sci. 2007 Jul 15;258(1-2):123-7. PubMed: 17462671

Protective APP Mutation Found—Supports Amyloid Hypothesis

RESEARCH NEWS 2012-07-13 Research News Does β amyloid accumulation drive Alzheimer’s disease? In favor of this idea, numerous known mutations in amyloid precursor protein step up Aβ production and lead to early onset AD. Critics of the theory contend, however, that familial AD ma

Paper Alert: DIAN Biomarker Data Show Changes Decades Before AD

RESEARCH NEWS 2012-07-13 Research News Biomarker data from the Dominantly Inherited Alzheimer Network (DIAN) paint a sobering picture, showing that a cascade of pathophysiological changes begins decades before a person is likely to develop familial Alzheimer’s disease. Alzforum h